Annette Gilchrist, Ph.D.

Associate Professor
Downers Grove, IL

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About

Since joining Midwestern University I have provided oversight for numerous Pharmacy, Dental, Biomedical, and Medical students working for Research elective credit or as Federal Work Study students.  I have served as a thesis advisor for four MBS students. Eighteen students have received summer Fellowship Awards under my mentorship. I have served as the preceptor for four CCOM students performing academic rotations.  During the summer of 2016, I served as an Intern Advisor to a student from the University of Kentucky Biomedical Program. In addition, two international exchange students (one from Pisa, Italy and one from Istanbul, Turkey) have worked in the laboratory under my direction.  

Title
Associate Professor

Campus
Downers Grove, IL

College
Chicago College of Pharmacy
College of Graduate Studies - IL

Department
Pharmaceutical Sciences

Program
Pharmacy

Call My
Office

630-515-6117

Send Me
a Message

agilchrist@midwestern.edu

Education

University of Connecticut - Health Center | 1995 | Ph.D.
University of Connecticut | 1990 | M.S.
University of Central Oklahoma | 1987 | B.S.

Courses Taught

Midwestern University, PTHE 1728, Pharmacology, Guest Lecturer on Oncology agents (2 contact hours)

Midwestern University, BISCD 0556, Research Design and Methodology, Guest Lecturer on Clinical Trials (2 contact hours)

Midwestern University, PPRAD 1783, Clinical Pharmacokinetics, Guest Lecturer on Pharmacogenomics (2 contact hours)

Midwestern University, PSCID 1384, Advanced Topics in Pharmacogenomics, a 2 credit hour elective course for PSII and PSIII students at Chicago College of Pharmacy (Course Director, Instructor, 4-6 contact hours)

Midwestern University, PSCID 1761, Principles of Drug Action I, a 2 credit hour required course for PSIII students at the Chicago College of Pharmacy (Course Director, Sole Instructor, 22-24 contact hours)

 

Research

I am a broadly trained scientist with an MS in Biochemistry, and a PhD in Immunology.  In the interim between completing my MS and starting my PhD I worked as a Research Associate at Pfizer on an osteoporosis project. This experience peaked my interest in translational applications of basic research, and as a consequence, I have successfully patented several innovative methodologies to examine G Protein Coupled Receptors (GPCRs) (US Patents 6,559,128; 7,208,279; 7,294,472; 8,193,151). My contribution to science include 49 publications with over 3000 citations (h-index 26, i10-index 34, R-score 34.79). Through the years I have studied numerous GPCRs including the visual receptor rhodopsin, the thrombin receptor PAR1, the chemokine receptors CCR1 and CCR5, and the free fatty acid receptor FFA2. GPCR drug action is much more nuanced than previously recognized.  Rather than simply turning the receptors on or off through agonists and antagonists respectively, we look to identify pathway selective “biased” drugs that may provide a mechanism for reducing unwanted side effects.

 

Publications

  1. Priyadarshini, M, Villa, SR, Fuller, M, Wicksteed, B, Mackay, CR, Alquier, T, Poitout, V, Mancebo, H, Mirmira, RG, Gilchrist, A, Layden, BT.  An acetate-specific GPCR, FFAR2, regulates insulin secretion. Mol Endocrinol. 2015 Jul;29(7):1055-66. PMCID: PMC4484778
  2. Gilchrist, A, Stern, PH. Chemokines and Bone. Clin Rev Bone Miner Metab 2015 June 13:61-82.
  3. Curtis, MJ, Bond, RA, Spina, D, Ahluwalia, A, Alexander, SPA, Giembycz, MA, Gilchrist, A, Hoyer, D, Insel, PA, Izzo, AA, Lawrence, AJ, MacEwan, DJ, Moon, LDF, Wonnacott, S, Weston, AH, McGrath, JC. Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol. 2015 Jul;172(14):3461-71. PMCID: PMC4507152
  4. Anthonius de Boer, A, Cohen, AF, Ferro, A, Flockhart, DA, Gilchrist, A, Isbister, G, Loke, YK, Ross, S, Somogyi, AA, Webb, AJ. Editors' Report for 2015, December 2015. Br J Clin Pharmacol. 2016 81(1):6-7 PMID: 26711189
  5. Mombers, C, Legako, K, Gilchrist, A. Identifying medical wearables and sensor technologies that deliver data on clinical endpoints. Br J Clin Pharmacol. 2016 81(2):196-8 PMID: 26542184
  6. Priyadarshini, M, Wicksteed, B, Schlitz, GE, Gilchrist, A, Layden, B. SCFA Receptors in Pancreatic b-Cells: Novel Diabetes Targets? Trends Endocrinol Metab. 2016 27 (9): 653-664 PMID: 27091493
  7. Cohen, A, Pattanaik, S, Kumar, P, Bies, RR, de Boer, A, Ferro, A, Gilchrist, A, Isbister, GK, Ross, S, Webb, AJ.  Organised crime against the academic peer review system. 2016. Br J Clin Pharmacol. 81(6): 1012–1017 PMID: 27211251
  8. Villa, SR, Priyadarshini, M, Fuller, MH, Bhardwaj, T, Brodsky, MR, Angueira, AR, Mosser, RE, Carboneau, BA, Tersey, SA, Mancebo, H, Gilchrist, A, Mirmira, RG, Gannon, M, Layden, BT. Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival. Sci Rep. 2016 6:28159 PMID: 27324831
  9. Villa, SR, Mishra, R, Zapater, J, Gilchrist, A, Mancebo, H, Schilitz, G, Layden, BT. Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion. Journal of Investigative Medicine 2017 65:1116-1124. PMID: 28784695
  10. Wang, SK, Gilchrist, A, Loukitcheva, A, Plotkin, B, Sigar, I, Gross, AE, O’Donnell, JH, Pettit, N. Buros, A, O’Driscoll, T., Rhodes, NJ, Bethel, C, Segreti, J, Charnot-Katsikas, A, Singh, K, Scheetz, MH. Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types Among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago. Anitmicrobial Agents Chemotherapy. 2018 62(8):pii: e00382-18. PMID: 29891607
  11. Gilchrist, A, Stern, PH. Editorial: Chemokines and Bone. Front Endocrinol (Lausanne). 2018 Jul 9:386. DOI: 10.3389/fendo.2018.00386. PMID: 30072949

Organizations

I have served as a Short Course Instructor on G protein couple receptor (GPCR)-Based Drug Discovery for many years including at the Drug Discovery Chemistry Annual Meeting, Annual World Preclinical Congress, and the Discovery on Target Annual Meeting. I am the faculty advisor to the MWU student chapter of Industry Pharmacists Organization (IPhO). I am a member of several professional orgnaizations including American Chemical Society (ACS), American Society for Pharmacology and Experimental Therapeutics (ASPET), American Society of Clinical Oncology (ASCO), British Pharmacological Society (BPS), and Society for Laboratory Automation and Screening (SLAS).

Grants

Muscarinic receptor signaling pathways in an aldosterone-producing cell line 09/01/18 - 08/31/20, MWU Multidisciplinary Award

Development of novel tools for assessing renal damage 07/01/19 - 6/31/20 Chicago College of Pharmacy Faculty Pilot Grant

Awards

Chair of LabRoots Conference Planning Committee for Drug Discovery virtual meetings (2018-2020)

International Editor for the British Journal of Clinical Pharmacology

Guest co-editor for Frontiers in Endocrinology Bone Research themed issue on “Chemokines and Bone” (http://journal.frontiersin.org/researchtopic/chemokines-and-bone-4013) published in 2017

Adjunct Faculty, Department of Pharmacology, Northwestern University, Chicago, IL

More Information

 Expert Consultant, Springboard Enterprises, Washington, DC

Expert Consultant, Foresight Science & Technology Inc., contractor for NIH SBIR Program Commercialization Support Program

Membership in Pharmacogene Variation (PharmVar) Consortium, www.PharmVar.org

Membership in Pharmacogenomics Research Network (PGRN), pgrn.org