Program Director
Downers Grove, IL
Title
Program Director
Campus
Downers Grove, IL
College
Chicago College of Osteopathic Medicine
College of Dental Medicine-Illinois
College of Graduate Studies - IL
Department
Biomedical Sciences
Program
Biomedical Sciences (M.A.)
Biomedical Sciences (M.B.S.)
Dental Medicine
Osteopathic Medicine
Endocrine Physiology - Physician Assistant Studies students, Physical Therapy students, Masters in Biomedical Sciences students, Master of Arts in Biomedical Sciences students
Gastrointestinal Physiology - Osteopathic Medical students, Physician Assistant Studies students, Physical Therapy students, Masters in Biomedical Sciences students, Master of Arts in Biomedical Sciences students
Glucose transporters in pancreatic beta cells.
The glucose transporter, GLUT2, shuttles glucose across the beta cell plasma membrane. In the cytosol of the beta cell, generation of ATP by glycolysis leads to secretion of insulin, a hormone that promotes glucose uptake by glucose-independent cells, such as skeletal muscle. In patients diagnosed with type 2 diabetes mellitus (T2DM), glucose transport across the beta cell plasma membrane may be impaired. Studies suggest that GLUT2 transporters may be altered in obese mouse models of T2DM. Research in the lab investigates changes in beta cell GLUT2 transporters during the development of insulin resistance.
Evans CE, LePard KJ, Kwak JW, Stancukas MC, Laskowski S, Dougherty J, Moulton L, Glawe A, Wang Y, Leone V, Antonopoulos DA, Smith D, Chang EB, Ciancio MJ. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS ONE 2014; 9(3): e92193. Click here for Evans et al 2014
LePard KJ, Cellini J. Age-dependent slowing of enteric axonal transport in insulin-resistant mice. World Journal of Gastroenterology 2013; 19(4): 482-491. doi:10.3748/wjg.v19.i4.482. Click here for LePard & Cellini, 2013
Cellini J, Pommier R, Porter R, LePard, KJ. Enhanced nerve-stimulated muscarinic and neurokinin contractions of ileum from streptozotocin guinea-pigs. Autonomic and Autocoid Pharmacology 2012; 32: 23-39. PMID: 22676206 Click here for Cellini et al 2012
Cellini J, Zaura Jukic AM, LePard KJ. Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs. Autonomic Neuroscience: Basic and Clinical. 2011 Dec 7;165(2):178-90. PMID: 21880552 Click here for Cellini et al 2011
Cellini J, DiNovo K, Harlow J, LePard KJ. Regional differences in neostigmine-induced contraction and relaxation of stomach from diabetic guinea pig. Autonomic Neuroscience: Basic and Clinical. 2011 Feb 24; 160(1-2):69-81. PMID: 21075692. Click here for Cellini et al 2011
LePard KJ. Student demonstration of relationship between intestinal slow waves and phasic contractions. Advances in Physiology Education 2005 Jun;29(2):131-2. PMID: 15905161, Click here for LePard KJ 2005
LePard KJ. Choline acetyltransferase and inducible nitric oxide synthase are increased in myenteric plexus of diabetic guinea pig. Autonomic Neuroscience 2005 Mar 31;118(1-2):12-24. PMID: 15795174, Click here for LePard KJ 2005
LePard KJ, Ren J, Galligan JJ. Presynaptic modulation of cholinergic and noncholinergic fast synaptic transmission in the myenteric plexus of guinea pig ileum. Neurogastroenterology and Motility 2004 Jun;16(3):355-64. PMID: 15198658, Click here for LePard et al 2004
Membership in Scientific/Professional Organizations:
American Physiological Society
National Association of Advisors for the Health Professions (NAAHP)
Central Association of Advisors for the Health Professions (CAAHP)
American Diabetes Association
2011 Item Writer of the Year, COMLEX-USA Level 1 exam, National Board of Osteopathic Medical Examiners
National Faculty, Foundational Biomedical Sciences, National Board of Osteopathic Medical Examiners
