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Pennsylvania State University | 1994 | B.S.
Downers Grove, IL
Downers Grove, IL
Chicago College of Osteopathic Medicine
Chicago College of Pharmacy
College of Dental Medicine-Illinois
College of Graduate Studies - IL
Biomedical Sciences (M.A.)
Biomedical Sciences (M.B.S.)
Physician Assistant Studies
I teach pharmacology of infectious diseases and central nervous system for medical, pharmacy, dental, PA, optometry, and biomedical masters programs.
Cadmium (Cd2+) is a toxin that accumulates in the body through contaminated foods, cigarette smoke, and occupational/environmental exposure. Although Cd2+ is most detrimental to the kidneys, liver and lungs, some research suggests that exposure may influence the incidence of pancreatic cancer or diabetes. The mechanism behind Cd2+ entry, as well as the effect of Cd2+ on a cellular level, are not well understood. Using Ca2+- and Zn2+-selective fluorescent probes in the mouse pancreatic beta cell line, MIN6, we demonstrated that Cd2+ enters through voltage-gated calcium channels (Malaiyandi et al., 2019). We also observed that Cd2+ accumulates under basal (non-depolarizing) conditions, albeit more slowly. Our present work uses a pharmacological approach to explore the role of transient receptor potential (TRP) channels in intracellular Cd2+ accumulation.
Students interested in working with us should know that fluorescence methodologies and equipment are highly amenable to novice researchers, for a number of reasons: (i) the necessary devices are easy to operate, therefore researchers can obtain data after brief training periods; (ii) data generation is observed real-time, which allows the luxury and gratification of immediate experimental evaluation; and (iii) a vast array of available fluorescent probes permits the measurement of a large variety of cellular processes including ion fluxes, membrane potential, and mechanisms of cell death. We have mentored dozens of graduate and undergraduate students from all types of health sciences programs. Most have presented their work at regional or national meetings, and many are co-authors on posters and publications. Please contact us if you are interested.
LM Malaiyandi, H Sharthiya, AN Barakat, JR Edwards, KE Dineley (2019) Using FluoZin-3 and fura-2 to monitor acute accumulation of free intracellular Cd2+ in a pancreatic beta cell line. Biometals 32(6):951-964.
JS Borchert, *B Wang, *M Ramzanali, LM Malaiyandi, AB Stein, KE Dineley (2019) A comparison of adverse events associated with insomnia drugs in patient online reviews and the FAERS database. Journal of Medical Internet Research. 21(11): e13371.
KE Dineley, LM Malaiyandi (2018) Histamine and Antihistamines. In: Brody’s Human Pharmacology, 6th Edition (Edited by L Wecker & RJ Theobald)
KE Dineley, LM Malaiyandi (2018) Respiratory Disorders and Their Treatment (Includes asthma and COPD). In: Brody’s Human Pharmacology, 6th Edition (Edited by L Wecker & RJ Theobald)
LM Malaiyandi, LA Potempa, *N Marschalk, P Jungsuwadee, KE Dineley (2018) Alkylating agent cytotoxicity associated with O6-methylguanine. In: Apoptosis & Beyond: The Many Ways Cells Die (Edited by J Radosevich)
LM Malaiyandi, H Sharthiya, *N Surachaicharn, *Y Shams, *M Arshad, C Schupbach, PG Kopf, KE Dineley. (2018) M3-subtype muscarinic receptor activation stimulates intracellular calcium oscillations and aldosterone synthesis in human adrenocortical HAC15 cells. Mol Cell Endocrinol 478:1-9.
LM Malaiyandi, H Sharthiya, KE Dineley (2016) Fluorescence detection of intracellular cadmium with Leadmium Green. Biometals 29(4): 625-635.
Member, American Association of Colleges of Pharmacy
Member, American Society for Pharmacology & Experimental Therapeutics
Member, Endocrine Society
Teacher of the Year, Roosevelt College of Pharmacy, Class of 2015
Student Award for Creative Teaching, Roosevelt University College of Pharmacy
Award for Excellence in Research and Scholarship, Francis Marion University
Penn Stater of the Quarter Award (New Kensington Campus)
Doctoral Dissertation with Honors, University of Pittsburgh Department of Molecular Pharmacology
Marian Kies Memorial Award for exceptional dissertation work in the neurosciences, American Society of Neurochemistry.
Individual Predoctoral Fellowship, American Heart Association, Pennsylvania-Delaware Affiliate