Kyle K. Henderson, Ph.D.

Associate Professor
Downers Grove, IL

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Dr. Henderson received his Ph.D. in Integrative Physiology at Kansas University Medical Center in 2001 with studies focusing on the oxygen transport system and effects of exercise and acclimatization to hypoxia.  He completed his Postdoctoral training on endothelial function, diet and exercise using a swine model at the University of Missouri-Columbia in 2004; with additional Postdoctoral training on cell signaling in the Department of Pharmacology and Experimental Therapeutics at Loyola University. In 2007 he became an Assistant Professor at the Cardiovascular Institute at Loyola University Chicago. During this time he served as an interim Small Animal Core Director for animal models of heart failure. In 2011, he joined Midwestern University and was promoted to Associate professor with tenure in 2016.  His research now focuses on the mechanisms and efficacy of Osteopathic Manipulative Medicine on the the cardio-pulmonary systems and cranial rhythmic impulse.

Associate Professor

Downers Grove, IL

Chicago College of Optometry
Chicago College of Osteopathic Medicine
College of Dental Medicine-Illinois
College of Graduate Studies - IL
College of Health Sciences - IL


Biomedical Sciences (M.A.)
Biomedical Sciences (M.B.S.)
Dental Medicine
Osteopathic Medicine
Physical Therapy
Physician Assistant Studies

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Kansas University Medical Center | 2001 | Ph.D.
University of Missouri-Columbia | 1993 | B.Sc.Ed.

Courses Taught

Chicago College of Pharmacy, Midwestern University                                                        

          1524 &1525 Human Physiology: Body Water, Respiratory, Renal & Acid Base Physiology   Lecturer/Director          2011-Present

College of Dental Medicine-Illinois, Midwestern University                                                           

          IBSSD 1534 Cardiovascular and Respiratory Systems:                                                         Lecture/Director           2015-Present 

          IBSSD 1540 Renal and Acid Base Physiology                                                                       Lecturer                        2019-Present

Chicago College of Health Sciences, Midwestern University                                              

          1511 Human Physiology: Body Water, Respiratory, Renal & Acid Base Physiology              Lecturer                        2013-Present

Chicago College of Osteopathic Medicine, Midwestern University                                     

          1501 & 1502 Human Physiology: Small Groups, Acid Base Physiology                                Lecturer                        2011-Present

Chicago College of Optometry, Midwestern University                                            

          1530 & 1531 Human Physiology: Body Water, Respiratory, Renal & Acid Base Physiology Lecturer                         2017-Present


Osteopathic Research:  With an appointment in the Chicago College of Osteopathic Medicine at Midwestern University, I started learning about Osteopathic Manipulative Medicine (OMM). OMM treatments have proven efficacy, but lack physiological mechanisms to define their use as evidence based medicine.  In 2014, I requested and obtained a joint appointment in the Osteopathic Manipulative Medicine Department. Working with Dr. Kurt Heinking (Chair of the OMM Department) we are currently building various research programs that will focus on Osteopathic Manipulative Treatment (OMT).  This includes the effect of somatic dysfunction and fascial strain patterns on pulmonary function, the effect of HVLA on low back pain and sympathetic tone, and Cranial Osteopathic Manipulative Medicine. Because cranial osteopathy is one of the most difficult topics to teach and skill to master; we are working on ways to visualize and measure cranial motion and to identify mechanisms for volumetric changes. This line of research has multiple collaborative possibilities with Speech Language Pathology (Dr. Megan Cuellar), Physical Therapy (Dr. Janey Prodoehl), Dental Medicine (Dr. Charles Patterson and Dr. Larry Williams), and Clinical Integration (Dr. Mireille Rizkalla).


  1. Henderson, K.K., S. Danzi, J.T. Paul, G. Leya, I. Klein, and A.M. Samarel.  Myocardial infarction and low T3 syndrome:  effect of thyroid hormone replacement on left ventricular function. Circ. Heart Failure. 2:243-252, 2009.  
  2. Kottam, A., J. Dubois, A. McElligott and K.K. Henderson. Novel Approach to Admittance to Volume Conversion for Ventricular Volume Measurement.  Conf Proc IEEE Eng Med Biol Soc. 2011:2514-7, 2011.
  3. Govindan S., A. McElligott, S. Muthusamy, N. Nair, D. Barefield, J.L. Martin, E. Gongora, K.D. Greis, P.K. Luther, S. Winegrad, K.K. Henderson, and S. Sadayappan. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.  J Mol Cell Cardiol. Jan; 52(1): 154-64, 2012.
  4. Henderson, K.K., J. Parker, and K. Heinking.  Mountaineering-Induced Bilateral Plantar Paresthesia. J Am Osteopath Assoc. 2014; 114(7):549-555. doi:10.7556/jaoa.2014.108.
  5. Zafiratos, M.T., S. Manam, K.K. Henderson, K.H. Ramsey, A.K. Murthy. CD8+ T cells Mediate Chlamydia pneumoniae Induced Atherosclerosis in Mice. Pathogens and Disease 2015. Oct;73(7).
  6. Tamayo, C.A., M. Rizkalla, and K.K. Henderson. Cognitive, Behavioral and Emotional Empathy in Pharmacy Students: Targeting Programs for Curriculum Modification. Frontiers in Pharmacology 2016. April 7(96) : 1-8. 
  7. Rizkalla, M., K.K. Henderson, K. Huntington-Alfano, K.P. Heinking, N.D. Krumdick, A. Koronkiewicz, M. Knees, H. Hoffman, F. Elahi, and A. Impens. Does Osteopathic Manipulation Make a Neuropsychological Brain of Difference in Adults with Pain?  A BOD Study Protocol and Rational for a New Approach.  J Am Osteopath Assoc. 2018 Sept 1; 118(9): 614-622. 
  8. Rizkalla, M. and K.K. Henderson. Empathy and Osteopathic Manipulative Medicine:  Is It All in the Hands? J Am Osteopathic Assoc. 2018 Sept 1 ; 118(9) : 573-585.
  9. Li W, Gudipaty P, Li C, Henderson KK, Ramsey KH, Murthy AK. Intranasal immunization with recombinant chlamydial protease-like activity factor attenuates atherosclerotic pathology following Chlamydia pneumoniae infection in mice. Immunol Cell Biol. 2019 Jan;97(1):85-91. doi: 10.1111/imcb.12192. Epub 2018 Aug 23.PMID: 30051926 
  10. Zafiratos MT, Cottrell JT, Manam S, Henderson KK, Ramsey KH, Murthy AK. Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice. Microbes Infect. 2019 Mar;21(2):104-108. doi: 10.1016/j.micinf.2018.09.003. Epub 2018 Oct 4.PMID: 30292879 
  11. Barnett ME, Henderson KK, Elliott-Burke TL, Heinking KP. Osteopathic Manipulative Treatment of Chronic Pelvic Pain due to High-Tone Pelvic Floor Dysfunction. Osteopathic Family Physician, Vol. 15, no. 2, June 2023, pp. 12–18, doi:10.33181/13095.


Member: American Physiological Society

Member: Sigma Xi

Member: American Osteopathic Association   

Member: American Academy of Osteopathy (AAO)

Chair: AAO: Louisa Burns Osteopathic Research Committee


Title: Analytical Assessment of the Cranial Rhythmic Impulse

Agency: American Academy of Osteopathy

PI: Kyle K Henderson, PhD

Role: PI


Phi Zeta Research Award; Department of Biomedical Science; University of Missouri-Columbia

American Physiological Society: Environmental and Exercise Physiology Section; Gatorade Postdoctoral Award

Falk Cardiovascular Research Fellowship: Cardiovascular Institute, Loyola University Medical Center

Beck/Scanlon Cardiovascular Scientist Development Award: Cardiovascular Institute, Loyola University Medical Center

Chicago Children’s Heart Association: Community Service Award

American Heart Association:  2013 Research Champion of the Year

American Heart Association: 2014 Chicago Marathon Team Member