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University of Wisconsin - Madison | 1994 | B.S.
College of Pharmacy
ASPH is an enzyme essential for embyrological development, including proliferation and migration. Tumors inappropriately over-express ASPH, resulting in tumor proliferation, invasion and metastasis. Cancers that over-express ASPH include liver, lung, pancreatic, breast, ovarian and brain cancers. ASPH small molecule inhibitors developed in the Olsen Laboratory have a demonstrated ability to suppress tumor proliferation and metastasis in in vitro and in vivo models of numerous cancers. Anti-ASPH antibodies have also been developed for both diagnostic and therapeutic applications. Other research in the Olsen Laboratory involves the rational design and synthesis of closely related enzymes, including FTO, FIH, TET1-3, and PHD1-3.
Zheng G, Cox T, Tribbey L, Wang GZ, Iacoban P, Booher ME, Rowles J, Gabriel GJ, Bae N, He C, Olsen MJ. “Synthesis of a FTO Inhibitor with Anticonvulsant Activity.” ACS Chemical Neuroscience. 5(8):658-65, 2014.
Aihara A, Huang C-K, Olsen MJ, Lin Q, Chung W, Dong X, Wands JR. “A Cell Surface β-Hydroxylase is a Biomarker and Therapeutic Target for Hepatocellular Carcinoma” Hepatology. 60(4):1302-13, 2014.
Dong X, Lin Q, Aihara A, Li Y, Huang C-K, Chung W, Tang Q, Chen X, Carlson R, Nadolny C, Gabriel G, Olsen MJ, Wands JR. “Aspartate β-Hydroxylase Expression Promotes a Malignant Phenotype Through Notch Activation and is a Therapeutic Target for Pancreatic Cancer” Oncotargets. 6(2):1231-48, 2015.
Iwagami Y, Huang CK, Olsen MJ, Thomas JM, Jang G, Kim M, Lin Q, Carlson RI, Wagner CE, Dong X, Wands JR. “Aspartate β-hydroxylase Modulates Cellular Senescence via Glycogen Synthase Kinase 3β in Hepatocellular Carcinoma” Hepatology, 63(4):1213-26, 2016.
Huang CK, Iwagami Y, Aihara A, Chung W, de la Monte S, Thomas JM, Olsen M, Carlson R, Yu T, Dong X, Wands J. “Antitumor Effects of Second Generation of beta-hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression.” PLoS One, 11(3):e0150336, 2016.
Singh B, Kinne HE, Milligan RD, Washburn LJ, Olsen M, Lucci A. “Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge” PLoS One, 11(7):e0159072, 2016.
Perczel A, Atanasov AG, Sklenář V, Nováček J, Papoušková V, Kadeřávek P, ?ídek L, Kozłowski H, Wątły J, Hecel A, Kołkowska P, Koča J, Svobodová-Vařeková R, Pravda L, Sehnal D, Horský V, Geidl S, Enriz RD, Matějka P, Jeništová A, Dendisová M, Kokaislová A, Weissig V, Olsen M, Coffey A, Ajuebor J, Keary R, Sanz-Gaitero M, van Raaij MJ, McAuliffe O, Waltenberger B, Mocan A, Šmejkal K, Heiss EH, Diederich M, Musioł R, Košmrlj J, Polański J, Jampílek J. “The Eighth Central European Conference “Chemistry towards Biology”: Snapshot.” Molecules, 21(10). pii: E1381 2016.
Sturla LM, Tong M, Hebda N, Gao J, Thomas JM, Olsen M, de la Monte SM. “Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas.” Heliyon, 2(12):e00203, 2016.
Mucaji P, Atanasov AG, Bak A , Kozik V, Sieron K , Olsen M , Pan W, Liu Y, Hu S, Lan J, Haider N, Musiol R , Vanco J, Diederich M, Ji S, Zitko J, Wang D, Agbaba D, Nikolic K, Oljacic S , Vucicevic J, Jezova D, Tsantili-Kakoulidou A, Fotios Tsopelas F, Giaginis C, Kowalska T , Sajewicz M , Silberring J , Mielczarek P, Smoluch M, Jendrzejewska I, Polanski J, Josef Jampilek J. “The Fourty Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot.” Molecules, 22(11). pii: E1848 2017.
American Chemical Society
Camille & Henry Dreyfus Foundation Olsen (PI) 01/01/2008 – 12/31/2008
Special Grant Program in the Chemical Sciences
Novel Chemistry Displays and Assessment for the Panhandle Plains Historical Museum
USDA NRI Grant Parker (PI) 01/01/2008 – 12/31/2011
ABATEMENT OF PHENOLIC AND INDOLIC VOC EMISSIONS FOR ODOR CONTROL AT ANIMAL FEEDING OPERATIONS
USDA NRI Seed Grant Olsen (PI) 01/01/2006 – 12/31/2007
BIOREMEDIATION OF ODOR EMISSIONS FROM ANIMAL FEEDING OPERATIONS
Research Corporation Olsen (PI) 01/01/2006 – 12/31/2007
Cottrell College Award (Tuscon, AZ)
Directed evolution of chondroitinase B using flow cytometry and cell surface display technology