Mark Olsen, Ph.D.

Associate Professor
Glendale, AZ

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Title
Associate Professor

Campus
Glendale, AZ

College
College of Pharmacy
Glendale Campus

Department
Pharmaceutical Sciences

Program
Pharmacy

Call My
Office

623-572-3568

Send Me
a Message

molsen@midwestern.edu

Education

University of Texas at Austin | 2003 | Ph.D.
University of Wisconsin - Madison | 1994 | B.S.

Research

ASPH is an enzyme essential for embyrological development, including proliferation and migration.  Tumors inappropriately over-express ASPH, resulting in tumor proliferation, invasion and metastasis.  Cancers that over-express ASPH include liver, lung, pancreatic, breast, ovarian and brain cancers.  ASPH small molecule inhibitors developed in the Olsen Laboratory have a demonstrated ability to suppress tumor proliferation and metastasis in in vitro and in vivo models of numerous cancers.  Anti-ASPH antibodies have also been developed for both diagnostic and therapeutic applications.  Other research in the Olsen Laboratory involves the rational design and synthesis of closely related enzymes, including FTO, FIH, TET1-3, and PHD1-3.

Publications

Zheng G, Cox T, Tribbey L, Wang GZ, Iacoban P, Booher ME, Rowles J, Gabriel GJ, Bae N, He C, Olsen MJ. “Synthesis of a FTO Inhibitor with Anticonvulsant Activity.” ACS Chemical Neuroscience.  5(8):658-65, 2014.

 

Aihara A, Huang C-K, Olsen MJ, Lin Q, Chung W, Dong X, Wands JR. “A Cell Surface β-Hydroxylase is a Biomarker and Therapeutic Target for Hepatocellular Carcinoma” Hepatology.  60(4):1302-13, 2014.

 

Dong X, Lin Q, Aihara A, Li Y, Huang C-K, Chung W, Tang Q, Chen X, Carlson R, Nadolny C, Gabriel G, Olsen MJ, Wands JR. “Aspartate β-Hydroxylase Expression Promotes a Malignant Phenotype Through Notch Activation and is a Therapeutic Target for Pancreatic Cancer” Oncotargets.  6(2):1231-48, 2015.

 

Iwagami Y, Huang CK, Olsen MJ, Thomas JM, Jang G, Kim M, Lin Q, Carlson RI, Wagner CE, Dong X, Wands JR. “Aspartate β-hydroxylase Modulates Cellular Senescence via Glycogen Synthase Kinase 3β in Hepatocellular Carcinoma” Hepatology, 63(4):1213-26, 2016.

 

Huang CK, Iwagami Y, Aihara A, Chung W, de la Monte S, Thomas JM, Olsen M, Carlson R, Yu T, Dong X, Wands J. “Antitumor Effects of Second Generation of beta-hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression.” PLoS One, 11(3):e0150336, 2016.

 

Singh B, Kinne HE, Milligan RD, Washburn LJ, Olsen M, Lucci A. “Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge” PLoS One, 11(7):e0159072, 2016.

 

Perczel A, Atanasov AG, Sklenář V, Nováček J, Papoušková V, Kadeřávek P, ?ídek L, Kozłowski H, Wątły J, Hecel A, Kołkowska P, Koča J, Svobodová-Vařeková R, Pravda L, Sehnal D, Horský V, Geidl S, Enriz RD, Matějka P, Jeništová A, Dendisová M, Kokaislová A, Weissig V, Olsen M, Coffey A, Ajuebor J, Keary R, Sanz-Gaitero M, van Raaij MJ, McAuliffe O, Waltenberger B, Mocan A, Šmejkal K, Heiss EH, Diederich M, Musioł R, Košmrlj J, Polański J, Jampílek J. “The Eighth Central European Conference “Chemistry towards Biology”: Snapshot.” Molecules, 21(10). pii: E1381 2016.

 

Sturla LM, Tong M, Hebda N, Gao J, Thomas JM, Olsen M, de la Monte SM. “Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas.” Heliyon, 2(12):e00203, 2016.

 

Mucaji P, Atanasov AG, Bak A , Kozik V, Sieron K , Olsen M , Pan W, Liu Y, Hu S, Lan J, Haider N, Musiol R , Vanco J, Diederich M, Ji S, Zitko J, Wang D, Agbaba D, Nikolic K, Oljacic S , Vucicevic J, Jezova D, Tsantili-Kakoulidou A, Fotios Tsopelas F, Giaginis C, Kowalska T , Sajewicz M , Silberring J , Mielczarek P, Smoluch M, Jendrzejewska I, Polanski J, Josef Jampilek J. “The Fourty Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot.” Molecules, 22(11). pii: E1848 2017.

Organizations

American Chemical Society

Grants

Camille & Henry Dreyfus Foundation            Olsen (PI)                                                    01/01/2008 – 12/31/2008

Special Grant Program in the Chemical Sciences

Novel Chemistry Displays and Assessment for the Panhandle Plains Historical Museum

Role: PI

 

USDA NRI Grant                                Parker (PI)                                                             01/01/2008 – 12/31/2011

ABATEMENT OF PHENOLIC AND INDOLIC VOC EMISSIONS FOR ODOR CONTROL AT ANIMAL FEEDING OPERATIONS

Role: Co-PI

 

USDA NRI Seed Grant                      Olsen (PI)                                                              01/01/2006 – 12/31/2007 

BIOREMEDIATION OF ODOR EMISSIONS FROM ANIMAL FEEDING OPERATIONS

Role: PI

 

Research Corporation                         Olsen (PI)                                                              01/01/2006 – 12/31/2007

Cottrell College Award (Tuscon, AZ)

Directed evolution of chondroitinase B using flow cytometry and cell surface display technology

Role: PI