University of Lethbridge | 2008 | M.SC
University of Lethbridge | 2006 | B.Sc.
Dr. Nafisa M. Jadavji is a Neuroscientist. She is an Assistant Professor at Midwestern University and Research Professor at Carleton University. In 2012, she completed her doctoral training at McGill University in Montréal, Canada. Her laboratory investigates how the brain responds to different biological processes throughout the lifespan. Dr. Jadavji’s research has been published in Biochemical Journal, Neuroendocrinology, Experimental Neurology, Journal of Neuroscience, Human Molecular Genetics, Nutrition reviews, Toxicological Science, European Journal of Neuroscience, Neural Regeneration Research, and Neurobiology of Disease. Dr. Jadavji has been funded by the Federation of European Neuroscience Society (Europe), NeuroWIND (Germany), Canadian Association for Neuroscience, Canadian Institutes of Health Research, National Science & Engineering Research Council (Canada), International Brain Research Organization, Parkinson's disease Foundation (US), Burroughs Wellcome Fund (US) and Fonds de la recherché en santé Québec (Canada). She is a regular reviewer for the Journal of Cerebral Blood Flow and Metabolism, Neurotoxicity Research, Journal of Molecular Medicine and Neuroscience. Dr. Jadavji is an Editorial member for Frontiers in Nutrition and JSM Nutritional Disorders Journals. She is also the Chair of the Board of Directors for the Journal of Young Investigators (JYI), as well as a Board Member, eLife ambassador, and mentor with the Canadian Society for Nutrition program.
College of Graduate Studies - AZ
Biomedical Sciences (M.A.)
Biomedical Sciences (M.B.S.)
BMMAG/BMMSG 554 Molecular Cell Biology
The majority of the world’s population is growing older, in 2000, 10% of the total population of the world was over 60 years old, and is projected to increase to 21% by 2050 (United Nations, 2015) . The single most important societal threat to the ageing population is the cognitive decline resulting in loss of dignity, independence, and enormous pressure for resources. What we eat, our nutrition, is modifiable risk factor for diseases of aging. As people age their ability to get adequate amount of nutrition from our diets decreases.
The Jadavji Laboratory at Midwestern University investigates neurological diseases of aging. Our translational research uses model systems to understand functional outcome, mechanisms, and potential therapeutics.
We use an interdisciplinary approach to tackle these complicated human diseases. Using both in vitro and in vivo tools, the Jadavji laboratory investigates the pathogenesis and mechanisms associated with diseases of aging, as well as comorbidity interactions, and finally investigate theraputic options for diseases of aging that could potentially be translated to human patients.
Please visit www.jadavjilab.com for more details about our research group!
Jadavji NM*, Mosnier H, Kelly E, Lawrence K, Cruickshank S, Stacey S, McCall A, Dhatt S, Arning E, Bottiglieri T, Smith PD (Accepted for Publication) One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2019.104613 PMID: 3152543
Jadavji NM*, Emmerson JT, Shanmugalingam U, Willmore WG, MacFarlane AJ, Smith P. (2018) MTHFR-deficiency increases vulnerability to stroke: in vitro and in vivo. Experimental Neurology, 309:14-22. PMID: 30055159.
Emmerson JT, Murray LK, Jadavji NM*. (2017) Impact of one-carbon metabolism on neural regeneration in the central nervous system. Neural Regeneration,12: 1-2. (invited). PMID: 28852387.
Jadavji NM*, Emmerson JE, Willmore WG, MacFarlane AJ, Smith PD. (2017) B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103:89-100. PMID: 28396257.
Dam K, Füchtemeier M, Farr TD, Boehm-Strum P, Foddis M, Dirnagl U, Jadavji NM*. (2017) Deficiencies in methylenetetrahydrofolate reductase and dietary folic acid alter choline metabolism during chronic hypoperfusion. Behavioral Brain Research, 321:201-208. PMID: 28087280.
Jadavji NM*, Farr TD, Lips L, Khalil A, Boehm-Sturm P, Harms C, Foddis M, Füchtemeier M, Dirnagl. (2015) Elevated levels of homocysteine, deficiencies in folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283: 215-226. PMID: 2565513.
Murray LK, Jadavji NM* (In Press). The role of B-vitamin metabolism in Parkinson’s disease onset, pathology, and mechanisms. Nutrition Research Reviews. DOI: https://doi.org/10.1017/S0954422419000106 (IF=4.586). PMID: 31303188
Jadavji NM*, Murray LK, Emmerson JT, Rudyk CA, Hayley S, Smith PD. (2019) A genetic deficiency in one-carbon metabolism increases oxidative stress in a mouse mode of Parkinson’s disease. Toxicological Sciences. 169:25-33. (IF=4.398). PMID: 30726997.
Jadavji NM, Metz GA. (2009) Both pre- and post-treatment with experiential therapy is beneficial in 6-OHDA dopamine-depleted rat. Neuroscience, 158:373-86. (IF = 3.327). PMID: 19032978.
Jadavji NM, Kolb B and Metz GA. (2006) Enriched environment improves motor function in intact and dopamine-depleted rats: implications for Parkinson’s disease. Neuroscience, 140: 1127-1138. (IF = 3.327). PMID: 1667892.
Prieur EAK, Pjetri E, Ziesel S, Jadavji NM*. (2017) BHMT-deficiency results in brain atrophy and impairs memory in mice. Applied Physiology, Nutrition, and Metabolism, 42:1228-1231. PMID: 28715642.
Jadavji NM*, Wieske F, Dirgnal U, Winter C. (2015) Methylenetetrahydrfolate reductase deficiency alters levels of monoamine neurotransmitters, glutamate and gamma aminobutyric acid in brain tissue. Molecular Genetics and Metabolism and Genetics Reports, 3:1-4. PMID: 26937386.
Jadavji NM, Bahous R, Deng L, Wang XL, Malysheva O, Caudill MA, Bedell BJ, Rozen R. (2014) A mouse model for genetic variation in methionine synthase reductase exhibits mild hyperhomocysteinemia, short-term memory impairment and biochemical changes in hippocampus. Biochemical Journal, 461:205-12. PMID: 24800750.
Jadavji NM, Deng L, Leclerc D, Malysheva O, Caudill MA, Bedell BJ, Rozen R. (2012) Methylenetetrahydrofolate reductase deficiency in mice impairs motor and cognitive function, with morphological and neurobiochemical changes in cerebellum and hippocampus. Molecular Genetics and Metabolism, 106:149-159. PMID: 22521626.
Maternal nutrition contributions on offspring neurological health
Murray LK, Smith MJ, Jadavji NM. (2018) Maternal over supplementation with folic acid and its impact on neurodevelopment of offspring. Nutrition Reviews. 76:708-721. PMID: 30010929.
Jadavji NM*. (2017) The integrated stress response is not a target for diffuse white matter injury in premature infants. Journal of Neuroscience, 37: 11772-1173. PMID: 29212946.
Bahous R, Jadavji NM, Deng L, Cosin-Tomas M, Lu J, Malysheva O, Leung KY, Ho MK, Pallas M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R. (2017) High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Human Molecular Genetics, 26:888-900. PMID: 28069796.
Jadavji NM, Malysheva O, Caudill MA, Rozen R. (2015) MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in hippocampus in wild-type offspring. Neuroscience, 300: 1-9. PMID: 25956258.
Journal of Young Investigators (Chair, Board of Directors)
eLife Community (Ambassador)
Sigma XI (invited full member)
American Heart Association (member)
American Society for Nutrition (member)
Canadian Association for Neuroscience (member)
Canadian Society in Molecular Biosciences (member)
Canadian Nutrition Society (member)
Graduate Women in Science (member)
Society for Neuroscience (member)
World Stroke Organization (member)
Project: “Impact of methylenetetrahydrofolate reductase deficiency on vulnerability to stroke in a mouse model,” Carleton University Development Grant, Co-Applicant, $9600 CDN
Project: “Canadian Association of Postdoctoral Scholars 2016 National Survey Grant,” Burrough’s Wellcome Fund, Principal Applicant, $5000 USD
Project: “The impact of methylenetetrahydrofolate reductase (MTHFR) deficiency in a mouse model of Parkinson's disease,” Canadian Institutes of Health Research (CIHR) Master’s Award, Co-Supervisor, $17,500 CDN
Project: “Impact of MTHFR deficiency on cell viability and oxidative stress in astrocytes,” Natural Sciences and Engineering Research Council (NSERC): Undergraduate Student Research Award, Undergraduate, Principal Applicant, $4500 CDN
Project: “Impact of MTHFR deficiency on neuronal mechanisms,” Natural Sciences and Engineering Research Council (NSERC) Undergraduate Student Research Award, Principal Applicant, $4500 CDN
Project: “Impact of MTHFR deficiency on neuronal and astrocyte mechanism,” National Science & Engineering Research Council (NSERC), Principal Applicant, $90,000 CDN. *Application Ranked 4/69 for Cellular and Molecular Biology Competition
Project: “Impact of genetic and dietary deficiencies in folate metabolism on stroke in a female mouse model”, Council of Ontario Universities Postdoctoral Women’s Health Scholars Fellowship, Principal Applicant, $45000 CDN
Project: “Evaluation of folate metabolism on functional behavioural assessment and mechanism in a animal model of Vascular Cognitive Impairment,” Fonds de la recherché en santé Québec (FRSQ), Principal Applicant, $135,000 CDN
2019: Publons Top Reviewer in Neuroscience and Behavior 2018-19
2018: 2nd Place Aging and Chronic Disease, Emerging Leaders in Nutrition Science Poster Competition, American Society for Nutrition Meeting, $200 USD
2018: Finalist, Postdoctoral Competition, American Society for Nutrition Meeting, $250 USD
2016: Howard Hughes Medical Institute Fellowship: Cold Spring Harbor Scientific Writing Course, $700 USD
2016: Best Poster Presentation Award (postdoctoral level), FASEB Folic Acid, Vitamin B12, and One-Carbon Metabolism Meeting, Steamboat Springs, $500 USA
2015: Young Investigator Award, 10th International Nutrition and Diagnostics Conference, Prague, CZ
2015: Best Poster Award, Post-doctoral Association, Postdoctoral Research Day, University of Ottawa, Faculty of Medicine, $100 CDN