Sean Lynch, Ph.D.

Professor
Downers Grove, IL

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About

Sean Lynch is a faculty member in Midwestern University’s College of Graduate Studies.  He earned a B.Sc. in Biochemistry from Queen’s University Belfast and a Ph.D. in Nutrition & Biochemistry from Ulster University, followed by postdoctoral training in the United States. At
Midwestern University, he educates students in health profession degree programs. Besides teaching, he directs laboratory research investigating inflammation, lipoprotein biochemistry, and cardiovascular disease. Dr. Lynch serves as a manuscript reviewer for scientific journals and is a
member of the Editorial Board of the Journal of Trace Elements in Medicine & Biology. He is a member of the National Board of Osteopathic Medical Examiners’ National Faculty, where he served as Division Chair for Biochemistry from 2014 to 2019. Dr. Lynch holds memberships in the
Society for Redox Biology & Medicine and the American Society for Nutrition.

Title
Professor

Campus
Downers Grove, IL

College
Chicago College of Optometry
Chicago College of Osteopathic Medicine
Chicago College of Pharmacy
College of Dental Medicine-Illinois
College of Graduate Studies - IL

Department
Biochemistry and Molecular Genetics

Program
Biomedical Sciences (M.A.)
Biomedical Sciences (M.B.S.)
Dental Medicine
Optometry
Osteopathic Medicine
Pharmacy
Physician Assistant Studies

Send Me
a Message

slynch@midwestern.edu

Education

Queen's University of Belfast
Northern Ireland | 0 | B.Sc.
Ulster University
Northern Ireland | 0 | Ph.D.

Courses Taught

College of Graduate Studies (CGS)
 BIOCD 0520 Biochemistry II (Master of Biomedical Sciences)
 BIOCD 0570 Biochemistry II (Master of Arts in Biomedical Sciences)
 BIOCD 0847 Nutrition in Preventive Medicine (Master of Biomedical Sciences; Elective)
 BIOCD 0947 Nutrition in Preventive Medicine (Master of Arts in Biomedical Sciences; Elective)

Chicago College of Osteopathic Medicine (CCOM)
 BIOCD 1501 Biochemistry I – Human Clinical Biochemistry and Metabolism
 BIOCD 1502 Biochemistry II – Human Cell and Molecular Biology, Genetics and Nutrition
 BIOCD 1670 Clinical Nutrition – Pediatric Overweight (Elective)

College of Dental Medicine Illinois (CDMI)
 IBSSD 1502 Nutrition, Genetics and Cancer
 IBSSD 1610 Gastrointestinal System

Chicago College of Pharmacy (CCP)
 BIOCD 1554 Biochemistry I
 BIOCD 1555 Biochemistry II

Chicago College of Optometry (CCO)
 BIOCD 1590 Biochemistry for Optometry Students

College of Health Sciences (CHS)
 BIOCD 0552 Clinical Biochemistry and Nutrition (Physician Assistant Studies)

Research

Blood levels of high-density lipoprotein (HDL; the “good-cholesterol”) are inversely associated with risk for heart disease.  During inflammation, oxidation of HDL by a variety of pro-oxidants results in loss of its cardio-protective properties including its ability to protect low-density lipoprotein (LDL) from oxidative modification.  Research in my laboratory is currently investigating the role of thiocyanate (SCN-) in the oxidation of HDL by myeloperoxidase, an important mediator of inflammation.  SCN- serves as a physiological substrate for myeloperoxidase-dependent generation of pro-oxidant hypothiocyanous acid (HOSCN).  Quantitatively, however, chloride (Cl-), and not SCN-, is myeloperoxidase’s major substrate leading to the formation of hypochlorous acid (HOCl).  In contrast to HOSCN, which is generally regarded as a weak (but highly selective) pro-oxidant, HOCl is a very powerful pro-oxidant.5  Interestingly, while preliminary studies in our laboratory indicate that HOSCN can promote oxidation of HDL, incubation of HDL with myeloperoxidase and a physiological combination of SCN- and Cl- protects the lipoprotein from HOCl-mediated oxidation.  Thus, depending upon the conditions, SCN- appears to possess dual pro-/anti-oxidant characteristics.  Future research will investigate (a) the biochemical mechanism(s) by which SCN- protects HDL from myeloperoxidase (b) the ability of SCN- to prevent loss of HDL’s ability to protect LDL from oxidation (c) the effect of SCN- on other cardio-protective properties associated with HDL. 

Publications

Lynch SM. Hypobromous acid and loss of cardio-protective paraoxonase-1 activity from human plasma. Free Radical Biology and Medicine 128:S31;2018.

Meader R, Lynch SM. Reactive bromamines and loss of PON1 antioxidant enzyme activity from plasma high-density lipoprotein. Journal of the American Osteopathic Association 118:e113-e114;2018.

White C, Lynch SM. Hypobromous acid and oxidation of human high-density lipoprotein. Journal of the American Osteopathic Association 115:e35-e37;2015.

Lynch SM, Lorenz J, Klotz S. Inclusion of calcium during isolation of high-density lipoprotein from plasma maintains antioxidant function. Analytical Biochemistry 454:41-43;2014.

Kunes JP, Cordero-Koning KS, Lee LH, Lynch SM. Vitamin C attenuates hypochlorite-mediated loss of paraoxonase-1 activity from human plasma. Nutrition Research 29:114-122;2009.

Organizations

Member, Society for Redox Biology and Medicine (SfRBM); Member, American Society for Nutrition (ASN); National Faculty Member, National Board of Osteopathic Medical Examiners (NBOME); Editorial Board Member, Journal of Trace Elements in Medicine and Biology (JTEMB).