T. Bucky Jones, Ph.D.

Professor
Glendale, AZ

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About

Dr. Jones received her PhD in Neuroscience from The Ohio State University in 2004 and joined Midwestern University as an Assistant Professor in 2008 (Department of Anatomy). She was promoted to Associate Professor with Tenure in 2013 and to Professor in 2019.

Title
Professor

Campus
Glendale, AZ

College
College of Graduate Studies - AZ

Department
Anatomy

Program
Dental Medicine
Optometry
Osteopathic Medicine

Call My
Office

623-572-3207

Send Me
a Message

bjones1@midwestern.edu

Education

The Ohio State University | 2004 | Ph.D.
Washington State University | 1998 | M.S.
University of Washington | 1984 | B.A.

Courses Taught

AZCOM/AZPOD: Anatomical Sciences 1516/1517, 1526/1527 (Course Director), 1536/1537

OT: Neuroscience (Course Director)

CDMA/AZCOPT: Neuroscience (Module Leader)

Research

My current project is broadly aimed at determining the effects of the innate immune system response to CNS trauma in a novel Drosophila melanogaster model of traumatic brain injury (TBI). Specifically, we are interested in defining more precisely the mechanisms by which reactive oxygen species (ROS), including nitric oxide (NO) influence functional outcomes following TBI. 

My work in AD is designed to investigate the effects of infectious disease processes on AD pathology. This work is testing the overall hypothesis that chronic infection and concomitant inflammation in the brain that occurs as part of the host response to infection induces histopathological features characteristic of this neurodegenerative disorder. Over the past several years, I have begun work aimed at evaluating the effects of various genes known to play a role in AD utilizing two distinct mouse models: the 3xTg mouse that expresses human APP, PS1, and MAPT genes and mice that express human APOE risk alleles, with or without Ab, on the impact of microbial infection on various indices of pathology and inflammation in the CNS.

My work in AD has significant overlap with my research in CNS trauma in which I have been involved since 2001. Many of the neuroinflammatory mechanisms that are present in AD patients (i.e., changes in glial morphology and functional phenotype) are similar to inflammatory processes that occur following trauma and vascular injury to the CNS. These immune signaling pathways are evolutionarily conserved and homologous pathways are present in Drosophila. Thus, my newest work utilizing a Drosophila model will draw on my previous work but will allow us to investigate more fully, mechanisms that have not been able to be defined in more complex animals.

My primary research focus over the past 14 years has been in studying the role of neuroinflammation in recovery of function after spinal cord injury. My background in spinal cord trauma has provided me with extensive experience working with rats and mice, and in evaluating histological, morphological and functional characteristics of CNS-specific cells (e.g., microglia and lymphocytes).

Publications

Tehrani, A.Y., J.Z. Cui, T.B. Jones, E. Hotova, M. Castro, P. Bernatchez, C. van Breemen, M. Esfandiarei. (2020) Characterization of doxycycline-mediated inhibition of Marfan syndrome-associated aortic dilation by multiphoton microscopy. Scientific Reports, Apr 28; 10(1):7154. doi: 10.1038/s41598-020-64071-8

Kaufman JA & Jones TB. (2017). Viscerosensory Pathways. In DE Haines & GA Mihailoff (Eds.) Fundamental Neuroscience for Basic and Clinical Applications. (pp. 278-285). Philadelphia, PA: Elsevier.

TB Jones & JA Kaufman. (2017). Visceral Motor Pathways. In DE Haines & GA Mihailoff (Eds.) Fundamental Neuroscience for Basic and Clinical Applications. (pp. 430-441). Philadelphia, PA: Elsevier.

Perkins, M., Wolf AB, Chavira B, Shonebarger D, Meckel JP, Leung L, Ballina L, Ly S, Saini A, Jones TB, Vallejo J, Jentarra G, Valla J. Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E ε4 carriers. Journal of Alzheimer’s Disease, 2016 Apr 23; 53(1):95-106. doi: 10.3233/JAD-151205

T. Bucky Jones. Lymphocytes and Autoimmunity in Spinal Cord Injury. Experimental Neurology, 2014 Aug; 258: 78-90. doi: 10.1016/j.expneurol.2014.03.003.

Chloe N. Vaughn; Julia I. Iafrate, Jessica A. Henley, Edward K. Stevenson, Igor G. Shlifer, and T. Bucky Jones.  Cellular neuroinflammation in a lateral forceps compression model of spinal cord injury. The Anatomical Record, 2013 Aug; 296:1229-1246. doi: 10.1002/ar.22730

T.B. Jones, Kurt M. Lucin, and Phillip G. Popovich (2008). The Immune System of the Brain in A.D. Rey, G. Chrousos, H. Besedovsky (Eds.) Neuroimmune Biology, Volume 7: 127-144. Elsevier Science.

Organizations

Society for Neuroscience

American Association of Anatomists

Grants

Pending and Funded Extramural Grant Support

Exploring intestinal microbiota dysbiosis in transgenic Alzheimer’s disease mouse models

Arizona Dept. of Health Services (Arizona Alzheimer’s Research Center) 

PI: G. Jentarra, T. Bucky Jones, Co-PI      

Requested amount: $35,000

Funding period: 7/1/2021-6/30/2022

 

Cerebrovascular Dysfunction and Cognitive Decline in Aging APOE2, APOE3 and APOE4 Targeted-Replacement Mice; Arizona Department of Health Services RFGA No. ADHS 17-00007401.      

PI: D. Eckman, T. Bucky Jones, Co-PI

$225,000   

Funding period:   4/1/2018-2/28/2022

 

Identification and Culture of Microbes in Brain Tissue from Alzheimer’s Disease Patients and Controls

Arizona Dept. of Health Services (Arizona Alzheimer’s Research Center) 

PI: G. Jentarra, T. Bucky Jones, PI             

$13,257       

Funding period:  7/1/2020 - 6/30/2021