Angela Marie Mexas, DVM, PhD, DipACVIM, DipACLAM

Assistant Professor


Midwestern University
College of Veterinary Medicine
Cactus Wren Hall Room 336-L
19555 59th Ave.
Glendale, AZ 85308

Office: (623) 537-6379
e-mail: amexas@midwestern.edu

EDUCATION

Residency Training Laboratory Animal Medicine University of Pennsylvania 2013        
Ph.D. Immunology North Carolina State University 2007
Residency Training Small Animal Internal Medicine North Carolina State University 2004
DVM Doctor of Veterinary Medicine  Colorado State University 1999
B.S. Microbiology Colorado State University 1996

RESEARCH SUMMARY

My research has focused on the pathogenesis of feline immunodeficiency virus (FIV) in cats, and the role of regulatory T cells during the acute phase of FIV infection. More recently, I studied HIV latency and virus reservoirs during anti-retroviral therapy and have developed an interest in studying the role of interferons during acute and chronic retroviral infections. With this experience, I hope to develop clinical trials aimed at improving the management of chronic diseases in companion animals. I am also interested in studies aimed at improving the husbandry and welfare of animals used in research.

Scientific fields of interest:

Immunology/ Infectious diseases/ Veterinary oncology

Project I:

Systemic cytokine levels in health and disease

Project II:

Evaluating a leukocyte filter-sparing technique for cell salvage

Project III:

Pharmacokinetics and pharmacodynamics of NSAID formulations in mice

Project IV:

Effects of canine periodontal disease and periodontal treatment on systemic markers of inflammation 

Selected Publications

Nasal Histopathology and Intracage Ammonia Levels in Female Groups and Breeding Mice Housed in Static Isolation Cages.
Mexas AM, Brice AK, Caro AC, Hillanbrand TS, Gaertner DJ.J Am Assoc Lab Anim Sci. 2015 Sep;54(5):478-86.

Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected].
Graf EH, Pace MJ, Peterson BA, Lynch LJ, Chukwulebe SB, Mexas AM, Shaheen F, Martin JN, Deeks SG, Connors M, Migueles SA, O'Doherty U.
PLoS One. 2013 Aug 7;8(8):e71879. doi: 10.1371/journal.pone.0071879. eCollection 2013. Erratum in: PLoS One. 2013;8(9).

Hypervitaminosis D in guinea pigs with α-mannosidosis.
Jensen JA, Brice AK, Bagel JH, Mexas AM, Yoon SY, Wolfe JH.
Comp Med. 2013 Apr;63(2):156-62.
 
Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration.
Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.
J Infect Dis. 2013 Jan 15;207(2):213-22.
 
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.
AIDS. 2012 Nov 28;26(18):2295-306.
 
Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency.
Pace MJ, Graf EH, Agosto LM, Mexas AM, Male F, Brady T, Bushman FD, O'Doherty U.
PLoS Pathog. 2012;8(7):e1002818.
 
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.
Graf EH, Mexas AM, Yu JJ, Shaheen F, Liszewski MK, Di Mascio M, Migueles SA, Connors M, O'Doherty U.
PLoS Pathog. 2011 Feb;7(2):e1001300.
 
CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism.
Fogle JE, Mexas AM, Tompkins WA, Tompkins MB.
AIDS Res Hum Retroviruses. 2010 Feb;26(2):201-16.
 
Veterinarians in biomedical research: building national capacity.
Buss DD, Atchison ML, Corps KN, Falkowski LB, Fox JG, Hendricks JC, Mexas AM, Rosol TJ, Stromberg BE.
J Vet Med Educ. 2009 Spring;36(1):62-9.
 
CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection.
Mexas AM, Fogle JE, Tompkins WA, Tompkins MB.
Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):263-72.
 
In vivo depletion of CD4+CD25+ regulatory T cells in cats.
Smithberg SR, Fogle JE, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, Dean GA.
J Immunol Methods. 2008 Jan 1;329(1-2):81-91.
 
Pulmonary lesions in cats with diabetes mellitus.
Mexas AM, Hess RS, Hawkins EC, Martin LD.
J Vet Intern Med. 2006 Jan-Feb;20(1):47-51.
 
Isolation of necrotoxigenic Escherichia coli from a dog with hemorrhagic pneumonia.
Breitschwerdt EB, DebRoy C, Mexas AM, Brown TT, Remick AK.
J Am Vet Med Assoc. 2005 Jun 15;226(12):2016-9, 2001.
 
Bartonella henselae and Bartonella elizabethae as potential canine pathogens.
Mexas AM, Hancock SI, Breitschwerdt EB.
J Clin Microbiol. 2002 Dec;40(12):4670-4.