Ann Revill, PhD

Assistant Professor

Ann Revill

Department of Physiology
Midwestern University
Agave 217E
Glendale, AZ 85308

Office: (623) 572-3724
Cell: (480) 843-3961
Lab: (623) 572-3487



University of Arizona PhD 2011
University of Guelph BSc (Hon) 2005


electrophysiology recording

Understanding the cellular and synaptic components that make up a neural circuit is key to unlocking the mysteries of how these components generate behaviour. We use the breathing circuit that controls the upper airway as a model system to address these fundamental research questions.

Breathing is a robust and adaptable rhythmic behaviour that maintains blood gases at appropriate values in the face of multiple perturbations including state (sleep vs. wakefulness), posture, development and maturation, and changing metabolic requirements (for example, during exercise). Breathing furthermore must be coordinated with other oromotor behaviours such as chewing, swallowing, and speaking. We are particularly interested in how the neurochemicals that modulate neural excitability can influence neuronal behaviour in this network.  

To address these research questions, we use a rodent model. We employ a rhythmic slice preparation for in vitro electrophysiology recordings including extracellular whole nerve recording and whole-cell recording (see image). We also perform anatomical experiments using viral transneuronal tracing, immunohistochemistry, and light and confocal microscopy. Students can expect to develop their own research project, and are encouraged to present their findings at local and national meetings.


Morphology of Dbx1 respiratory neurons in the preBötzinger complex and reticular formation of neonatal mice.
Akins VT, Weragalaarachchi K, Picardo MCD, Revill AL, Del Negro CA. 2017. Scientific Data. 4, Article number: 170097. doi:10.1038/sdata.2017.97.

Inhibition linearizes firing rate responses in human motor units: implications for the role of persistent inward currents.
Revill AL & Fuglevand AJ. 2017. Journal of Physiology. 595(1): 179-191. doi: 10.1113/JP272823.

Dbx1 precursor cells are a source of inspiratory XII premotoneurons.
Revill AL, Vann NC, Akins VT, Kottick A, Gray PA, Del Negro CA*, Funk GD*. 2015.  (*, co-anchor authors) eLife. 19;4. pii: e12301. doi: 10.7554/eLife.12301.

Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice.
Wang X, Hayes JA, Revill AL, Song H, Kottick A, Vann NC, LaMar MD, Picardo MC, Akins VT, Funk GD, Del Negro CA. 2014.  Elife. 3:e03427. doi: 10.7554/eLife.03427

P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.
Alvares TS*, Revill AL*, Huxtable AG, Lorenz CD & Funk GD. 2014.  Journal of Physiology 592: 3089-3111. doi: 10.1113/jphysiol.2013.268136. (*, co-first authors)