Christian C. Evans

Professor, Physical Therapy


  Christian C. Evans, PT, PhD
  Professor, Physical Therapy
  555 31st Street, AH 340E
  Downers Grove, IL 60515
  Office: 630-515-7249

  email: Evans@midwestern.edu

EDUCATION

The University of Illinois at Chicago. 808 South Wood Street, Chicago, IL 60612. Department of Physiology and  Biophysics.  Dates attended: 08/95- 01/2000.  PhD in Physiology & Biophysics received 5/7/2000. Thesis title: The Effects of a Familial Hypertrophic Cardiomyopathy-linked Mutation in Tropomyosin on Cardiac Function.

The University of Alabama at Birmingham. UAB School of Health Professions, WEBB 616, 1530 3rd Ave., S Birmingham, AL 35294. Physical Therapy Program. Dates attended: 01/91-12/92. MSPT degree received 12/92. Thesis title: The Effect of a Swim Training Protocol on Skeletal Muscle Motor Endplates of Streptozotocin-Induced Diabetic Rats.   

The Pennsylvania State University.  University Park, PA 16802.  Department of Agriculture and Environmental Science. Dates attended: 09/76-11/80. BS in Environmental Resource Management received 11/80.

LICENSURE

State of Illinois, Department of Professional Regulations.  Licensed Physical Therapist.

EMPLOYMENT

Professor (7/2013-present). Midwestern University, College of Health Science, Physical Therapy Program. 555 31st St. Downers Grove, IL 60515.

Associate Professor (7/2004-present) and tenured faculty.  Midwestern University, College of Health Science, Physical Therapy Program. 555 31st St. Downers Grove, IL 60515. Joint appointment as Associate Professor to MWU Biomedical Sciences Program, July 2013

Assistant Professor (1/2000-6/2004). Midwestern University, College of Health Science, Physical Therapy Program. 555 31st St. Downers Grove, IL 60515.  Instructor (6/99-1/00). Midwestern University, College of Health Science, Physical Therapy Program. 555 31st St. Downers Grove, IL 60515.

The University of Illinois at Chicago, Department of Physiology & Biophysics. 808 South Wood Street, Chicago, IL 60612. Teaching Assistant (07/ 1995- 8/1999).

Westlake Community Hospital. 1225 Lake St., Melrose Park, IL 60160. Staff Physical Therapist (12/1992-12/1994): The University of Illinois at Chicago Medical Center.  1740 W. Taylor St., Chicago, IL 60612-7232.

The University of Illinois at Chicago, Department of Physical Therapy. 1740 West Taylor Street , Chicago, IL 60612. Staff Physical Therapist (12/1991 - 12/1994).

Teaching Assistantship (01/1991-12/1991): The University of Alabama at Birmingham.  School of Health Related Professions, Department of Physical Therapy. WEBB 616, 1530 3rd Ave., S Birmingham, AL 35294.

RESEARCH

Our laboratory is interested in how exercise can be used to prevent or treat obesity and the related conditions of metabolic syndrome and type-2 diabetes. One model that we have experience using is a mouse model of high fat, diet-induced obesity (Jackson Labs C57B/6 mice) that exhibit many of the signs, symptoms and co-morbidities of human obesity seen in Western cultures.  Our model also incorporates sedentary lifestyle and we use exercise as an intervention to prevent HF-diet induced obesity.  One of the most interesting findings with this model is that exercise up-regulates the expression of heat shock protein 70 (Hsp70) in the gut.  This led us to examine an epithelial-specific transgenic mouse that over-expresses Hsp70 in the gut.  Similar to the finding with exercise, Hsp70 transgenic mice are protected from high fat diet-induced obesity, but yet have a normal phenotype in other ways. 

We are currently investigating the mechanisms whereby both exercise and Hsp70 over-expression protect against high fat diet-induced obesity (see proposed model below).  A novel mechanism for these effects is a change in the gut microbiota. We have found that high fat diets produce profound changes in the gut microbiota, but that both exercise and Hsp70 over-expression also alter the microbiota. Exercise or Hsp70-induced changes in gut microbes may underlie some of their protective effects.

Our laboratory involves integrated physiology with an emphasis on exercise and gut metabolism and how these impact inflammation and the development of obesity.  From a personal standpoint, I am a physical therapist and believe that exercise plays a fundamental and critical role in health, similar to the role of sleep and nutrition.  The effects of exercise go beyond just expending calories to balance out calorie intake.  Exercise activates anti-inflammatory and metabolic pathways that affect every system, including the gut, to promote health and prevent obesity.  Recent reports in the scientific literature about the beneficial effects of exercise in preventing brain atrophy in the elderly, in maintaining function in Parkinson's disease and in preventing the development of cancer are just some of the many profound ways it may promote health.  

PEER REVIEWED PUBLICATIONS

(journal articles and book chapters, 1998-present):

Swain AJ, and Evans CC. "The Effectiveness of a Home Exercise Program for a Young Athlete with Schmorl's Nodes: A Case Report." Global J Med Clin Case Reports 1 104.01 (2014). Available at: http://www.peertechz.com/Clinical-Case-Reports/GJMCCR-1-104.pdf

Evans CC, LePard KJ, Kwak JW, Stancukas MC, Laskowski S, Dougherty J, Moulton J, Glawe A, Wango Y, Leone V,  Antonopoulos DA, Smith D, Chang EB and Ciancio MJ. Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity.  PloS one, 2014;9(3), e92193. Available at: http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0092193&representation=PDF.

Hwang S, Hanke T, Evans CC. Automated Extraction of Community Mobility Measures from GPS Stream Data Using Temporal DBSCAN. Computational Science and Its Applications (ICCSA Meeting: Lecture Notes in Computer Science). 2013;7972:86-98. Available at: http://link.springer.com/chapter/10.1007%2F978-3-642-39643-4_7

Evans CC and Conroy C. Management of Patients with Type II Diabetes Residing at a Homeless Shelter: A Series of Case Reports. J Phys Ther. 2012;6(1):3-12. Available at: http://www.ejmanager.com/mnstemps/17/17-1359148026.pdf?t=1383149951

Evans CC, Hanke TA, Zielke D, Keller S, Ruroede K, Hwang S. Monitoring Community Mobility with Global Positioning System Technology after a Stroke: a Case Report. J. Neurol Phys Ther. June 2012:37(2). Available at: http://journals.lww.com/jnpt/Abstract/2012/06000/Monitoring_Community_Mobility_With_Global.4.aspx

Evans CC and Brooks G. Chapter 12: Electrocardiogram Interpretation, in Cardiovascular and Pulmonary Physical Therapy, Evidence and Practice. Frownfelter  D, Dean, E. 5th ed., Mosby-Elsevier, St. Louis, MO, March, 2012.

Evans CC, Schwarz L, Masihi M. Screening for Heart Disease in Athletes by Athletic Trainers and Sports Physical Therapists. J Sport Rehab. May 2008;17(2):171-185.

Evans CC and Brooks G. Chapter 12: Electrocardiogram Interpretation, in Cardiovascular and Pulmonary Physical Therapy, Evidence and Practice. Frownfelter  D, Dean, E. 4th ed., Mosby-Elsevier, St. Louis, MO, 2006.

Evans CC and Cassady SL. Sudden Cardiac Death in Athletes: What the Sports Rehabilitation Specialist Needs to Know. J. Sport Rehab., August 12(3):259-71, 2003.

Evans CC, Wolska BW, Pena JW, Phillps R, Muthuchamy M, Wieczorek DF, Solaro RJ. Altered hemodynamics in transgenic mice harboring a mutant tropomyosin (Asp175Asn) linked to familial hypertrophic cardiomyopathy. Am J Physiol, Heart Circ Physiol. 279(5):H2414-23, 2000.

Wolska BW, Keller RS, Evans CC, Palmiter KA, Phillips RM, Muthuchamy M, Oelenschlager J, Wieczorek DF, de Tombe PP, Solaro RJ.  Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells expressing b-tropomyosin. Circ. Res., April 84(7):745-51, 1999.

Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, Boivin GP, Wolska B, Evans CC,  Solaro RJ, Wieczorek DF. Mouse model of a familial hypertrophic cardiomyopathy mutation in a-tropomyosin manifests cardiac dysfunction. Circ. Res., 85(1): 47-56, 1999.

Rethinasamy P, Muthuchamy M, Hewett T, Boivin G, Wolska BW, Evans CC, Solaro RJ, Wieczorek DF. Molecular and physiologic effects of alpha-tropomyosin ablation in the mouse. Circ. Res., 82(1): 116-23, 1998.

PUBLISHED ABSTRACTS AND PRESENTATIONS (last 10 years only)

Chawla AS, Pytynia M, Glawe A, Lasemi N, Evans CC, Ciancio MJ. Over-expression of Epithelial Cell Heat Shock Protein 70 Prevents Diet-induced Obesity: Effects on Colonic Tight Junction Protein Expression.  Gastroenterology. In press.  Accepted for presentation as a poster at DDW, AGA, Washington, DC, May 2015. Abstract published online (Link).

Glawe A, Burnoski M, King A, Pytynia M, Evans CC, Ciancio MJ. Epithelial Cell Heat Shock Protein 70 Expression Alters the Gut Microbiota and Prevents Diet-induced Obesity. Gastroenterology. Presented as a poster at DDW, AGA, Washington, DC, May 2015. Abstract to be published online (in press).

Oakford MM and Evans CC. The Design, Implementation and Evaluation of a Community Group-Based Exercise Program for Older Adults:  A Programmatic Case Report. IPTA Spring Conference, Oakbrook, IL 4/23/12015. Platform Presentation. 

Hanke TA, Hwang S, Keller S, Zielke D, Hailey T, Evans CC. Measuring Post-Stroke Rehabilitation Community Mobility Using Global Positioning System Technology: A Pilot Study. APTA, CSM meeting, Indianapolis, IN, February 4-7, 2015. Status: presented as a poster. Abstract available at: https://apta-csm2015.abstractcentral.com/submission?

Lee KJ, Seo D, Glawe A, Pytynia M, Chawla A, Veen S, Howell B, Sacchetti S, Fakhoury A, Evans CC, Ciancio MJ. Heat Shock Protein 70 Significantly Alters Oral Microbiota and Prevents Obesity. J Dent Res 94 (Spec Iss A):4060, 2015 (www.iadr.org)

Glawe A, Harriett L, Pytynia M, LePard KJ, Evans CC, Ciancio MJ.  Continuous Epithelial Cell Heat Shock Protein 70 Expression Protects Against High Fat, Diet-Induced Obesity in Mice. Gastroenterology. 2014;146(5-S1):S-111-112. Abstract #592. Available at: Link. Last accessed 3/16/15. Platform presentation, DDW, Chicago, May, 2014. 

Anderson C and Evans CC. Does Inspiratory Muscle Training Improve Lung Function, Inspiratory Muscle Strength or Inspiratory Muscle Endurance in People with Duchenne Muscular Dystrophy? A Systematic Review. February 4th, 2014. Poster presentation #1009. APTA Combined Sections Meeting, February 2013. Abstract in Cardiopul Phys Ther J. 2013;24(4):40. Available online at: http://cpptjournal.org/pdfs/members/fulltext/2013/dec/CSM_2014_Platform.pdf

Kennedy K, Ryan J, Evans CC. Tailoring Physical Therapy Treatment to Achieve Optimal Function for a Patient with Multiple Sclerosis Receiving Intrathecal Baclofen Therapy: A Case Report.  Illinois Physical Therapy Association Fall Conference, November 9th, 2013. Poster presentation. Available at: http://c.ymcdn.com/sites/www.ipta.org/resource/resmgr/2013conference/poster_presentations.pdf

Kwak J, Ciancio MJ, Evans CC, Laskowski S, Dougherty J and LePard K.  Voluntary Exercise Prevents Diet-induced Obesity and Decreases the Proportion of Major Gut Phylum Bacteria Bacteroidites and Firmicutes.  Society for In Vitro Biology. Annual Conference, June 16th, 2013. Cell Dev Biol.- DOI 10.1007/s11626-013-9609-1. Abstract # A-1004. Available at: http://www.sivb.org/meetings/2013Assets/Animal%20Contributed%20Papers.pdf

Ciancio MF, Duminie S, Manalastas M, Evans CC, LePard K. Selectively Expressed Heat Shock Protein 70 Prevents Diet-induced Changes in Pancreatic Structure and Function. Presentation at 2012 World Congress on In Vitro Biology. June 3-7, 2012. Bellevue, WA. Abstract published at http://www.sivb.org/meetings/meeting_archive.htm.

O'Connell M and Evans CC. Physical Therapy Treatment of a Unilateral Total Knee Arthroplasty Using a Manual Therapy Approach: A Case Report. Illinois Physical Therapy Association, Fall Conference, October 12, 2012. Marriott Naperville Hotel, Naperville, Illinois (poster). 

Fuller D and Evans CC (presenter). Is Home-Based Pulmonary Rehabilitation as Effective as Hospital-Based for Patients with Chronic Obstructive Pulmonary Disease? A Systematic Review. Accepted for presentation at the American Physical Therapy Association Combined Sections Meeting, Poster #: 1158, February 9, 2012. Abstract in Cardiopulm Phys Ther J. Dec 2011;22(4):131. Available at: http://www.cpptjournal.org/pdfs/members/fulltext/2011/dec/Cardio_vol22no4.pdf

Hanke T (presenter) and Evans C. The Phenomenology of Participation and Its Quantification Using Global Positioning System Technology: an Ecological Perspective. World Confederation for Physical Therapy, World Congress Meeting, Amsterdam, Netherlands, June 20-23, 2011. Abstract Number: SI-PO-211-28-Thu. Available online at: http://www.abstractserver.com/wpt2011/planner/index.php?go=abstract&action=abstract_iplanner&absno=1404&WPT2011=h7d163u8po1r4kolb2j8tmt533&WPT2011=h7d163u8po1r4kolb2j8tmt533

LePard KJ (presenter), Manalastas M, Cellini J, Duminie S, Moulton L, Evans CC, Ciancio MJ. Exercise-Induced Pancreatic Hsp70 Correlates with Improved Glycemic Control in Diet-Induced Obese Mice. Digestive Disease Week Annual Meeting, May 7, 2011, Abstract published online at Digestive Disease Week. N&O-P5,Sa1816. (Available at: http://ddw.apprisor.net/DDW_PRES.cfm?id=2539)

CC Evans (presenter), LJ Moulton, C Stancukas, K. LePard, Ciancio MJ. Voluntary Exercise Prevents Diet-Induced Obesity. Presented at: Experimental Biology (FASEB), Washington, DC., April 12, 2011. Abstract published in J Fed Am Soc Exper Biol. 2011;25:1062.10. (Available at: http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/1062.10?sid=27fe1d2b-d019-4208-88d8-6a0c58c56bd3)

CC Evans (presenter), T Hanke, D Zielke, K Ruroede, A Martinez. Measuring Community Mobility with GPS Technology for a Person Recovering from a Stroke: A Case Report. Presented at: the APTA Annual Conference, Boston, MA. June 2010. ID: 732596. Abstract published online in Phys Ther J. June, 2010. (Available at: http://apps.apta.org/Custom/abstracts/pt2010/abstractsPt.cfm?m_id=28557)

Stancukas M, Evans CC, Wang Y, Devkota S, Drabik K, Antonopoulos D, Chang EB, LePard K, Ciancio MJ (presenter). Voluntary Exercise Alters Enteric Microbiota But Not Intestinal Transit. Digestive Disease Week. May, 2010. Abstract published online at Digestive Disease Week. #:W1843. (Available at: http://ddw.scientificposters.com/epsabstract.cfm?id=26)

Evans CC (presenter), Hanke T, Zielke D, Ruroede K, Martinez A. Reliability and validity of global positioning system technology in tracking community movement. Phys Ther. APTA Annual Conference, Baltimore, June 2009. PO-150-RR-TH. (Available at: http://apps.apta.org/Custom/abstracts/pt2009/abstractsPt.cfm?m_id=19628)

Priebe T (presenter) and Evans CC. Rehabilitation and Outcome in a Patient with a Traumatic Above the Elbow Amputation with Replantation: A Case Report. Poster presentation at Illinois Physical Therapy Association Annual Conference, September, 2008. Naperville, IL.

Conroy C (presenter) and Evans CC. Management of Patients with Diabetes Receiving Homeless Services. Platform presentation. World Physical Therapy Congress. June, 2007. Vancouver, Canada.

Conroy C and Evans CC (co-presenter). Management of Patients with Diabetes Receiving Homeless Services. Platform presentation. American Physical Therapy Association Combined Sections Meeting, February 2007. Boston, MA. Cardiopulm Phys Ther J. December 2006;17(4):145 (Abstract).

CC Evans (presenter), T Hanke, K O'Hagan. Use of Global Positioning System Technology to Monitor Physical Activity in a College Campus Environment: a Case Report. APTA Annual Scientific Conference. June 21st, 2006.

Evans CC (presenter). Kiichi Sagawa Young Investigator Competition (4th finalist).  Title: Mechanical support normalizes cardiac myofilament force-ATPase relationship in human heart failure.  Presented at the Cardiovascular Systems Dynamics Society meeting, Platform presentation. July, 2004. Banff, Alberta, Canada.