Gerald B. Call, Ph.D.

Professor of Pharmacology


Midwestern University
Arizona College of Osteopathic Medicine
Department of Pharmacology
214-5 Agave Hall
19555 N 59th Ave
Glendale, AZ 85308

Office: (623) 572-3711
Lab: (623) 537-6047
gcall@midwestern.edu

EDUCATION

B.S. Zoology Brigham Young University 1994
M.S. Zoology Brigham Young University 1996
Ph.D. Physiology University of Kansas Medical Center 2001

RESEARCH SUMMARY

I utilize the fruit fly (Drosophila melanogaster) in my research as a genetic model organism and have two major projects in my laboratory. 

First, I study Parkinson's disease (PD) in the fly and try to determine how to treat it.  We have recently found that phenotypes (symptoms) in a fly model of PD can be improved or even rescued when treated with nicotine (Chambers et al.).  We do not know how nicotine does this, but it has been found to be neuroprotective in other PD models.  Understanding how and why nicotine ameliorates the PD phenotype in our model is a current avenue of research. I collaborate with Dr. Lori Buhlman on this project.

Second, I have been studying the effects of anesthesia in the fly in an attempt to determine the molecular mechanism of commonly used clinical anesthetics.  In this process, we have found that CO2, the most common anesthetic used in flies, has long-term detrimental impacts on behaviors (Bartholomew et al.).  This is important, because it is possible that many researchers across the world utlize CO2 anesthesia without any regard to the effects it might have.  We are pursuing this effect and attempting to determine its mechanism.  I collaborate with Drs. Michael Quinlan and John VandenBrooks on this project.

RECENT PUBLICATIONS

Impaired climbing and flight behaviour in Drosophila melanogaster following carbon dioxide anaesthesia.
Bartholomew NR, Burdett JM, VandenBrooks JM, Quinlan MC, Call GB. Sci Rep. 2015 Oct 19;5:15298. doi: 10.1038/srep15298.

Computational tools for fitting the Hill equation to dose-response curves.
Gadagkar SR, Call GB.  J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:68-76. doi: 10.1016/j.vascn.2014.08.006.

Dissection and mounting of Drosophila pupal eye discs.
Tea JS, Cespedes A, Dawson D, Banerjee U, Call GB. J Vis Exp. 2014 Nov 9;(93):e52315. doi: 10.3791/52315

Nicotine increases lifespan and rescues olfactory and motor deficits in a Drosophila model of Parkinson's disease.
Chambers RP, Call GB, Meyer D, Smith J, Techau JA, Pearman K, Buhlman LM.  Behav Brain Res. 2013 Sep 15;253:95-102. doi: 10.1016/j.bbr.2013.07.020.

An airtight approach to the inebriometer: from construction to application with volatile anesthetics.
Dawson AG, Heidari P, Gadagkar SR, Murray MJ, Call GB. Fly (Austin). 2013 Apr-Jun;7(2):112-7. doi: 10.4161/fly.24142.

List of Complete Publications (Pubmed)