Jason A. Kaufman, Ph.D.

Associate Professor


Midwestern University
Arizona College of Osteopathic Medicine
Department of Anatomy
Agave Hall 201F
19555 N. 59th Ave.
Glendale, AZ 85308

Office: (623) 572-3717
e-mail: jkaufman@midwestern.edu

EDUCATION

B.A. Anthropology Columbia University (New York, NY) 1997
M.A Biological Anthropology Washington University (St. Louis, MO) 2001
Ph.D. Biological Anthropology Washington University (St. Louis, MO) 2004

EXPERIENCE

Postdoctoral Fellow (September 2004 - September 2008)

California Institute of Technology, Pasadena, CA, Division of Biology, with the research group of Prof. John M. Allman, Hixon Professor of Neurobiology.  Performed research on Von Economo neurons of anterior cingulate and frontoinsular cortices, believed to play a role in social cognition.  Performed research on comparative primate neuroanatomy using Diffusion-Weighted MRI (DW-MRI), and conducted histological validations of DW-MRI.  Experience in neuroimaging, histology, and stereology.

RESEARCH SUMMARY

Methodology in neuroimaging and neurohistology
The brain is a heterogeneous tissue with highly variable cytoarchitecture.  Investigation of neural substructure is traditionally performed on the macro-scale using imaging modalities such as MRI, or on the micro-scale using neurohistology.  My research focuses on new variants of MRI and histology, as well as methods that bridge the span between the macro-scale and micro-scale architecture of the brain.  I apply these methods to a variety of basic science questions, such as comparative neuroanatomy, as well as clinical questions, such as histopathology of Alzheimer Disease.

Research projects

Project I: My laboratory is working on next-generation methods of neurohistology that allow for imaging of large brain samples at cellular resolution.  Specifically, we are employing optical clearing methods such as CLARITY to render brain specimens transparent while maintaining the cytoarchitecture of proteins and nucleic acids.  These "cleared" brains can then be tagged for specific biomolecules and imaged using confocal fluorescence microscopy.

Project II: We are using optical clearing methods, as well as conventional histology, to investigate histopathology in Alzheimer Disease (AD).  Transgenic mouse models of AD allow us to investigate the expression of amyloid plaques and neurofibrillary tangles that are the hallmark of Alzheimer's.  By incorporating optical clearing methods, we hope to provide new methods to map Alzheimer's pathology and progression.

PUBLICATIONS

Martirosyan NL, Turner GH, Kaufman JA, Patel AA, Belykh E, Kalani MY, Theodore N, & Preul MC.  (2016)  Manganese-enhanced MRI offers correlation with severity of spinal cord injury in experimental models.  Open Neuroimag J 10: 139-147.  doi:10.2174/1874440001610010139.

Kaufman JA, Turner GH, Holroyd PA, Rovero R, & Grossman A.  (2013)  Brain volume of the newly discovered species Rhynchocyon udzungwensis (Mammalia: Afrotheria: Macroscelidea): implications for encephalization in sengis. PLoS ONE 8(3): e58667. doi:10.1371/journal.pone.0058667.

Kaufman JA, Tyszka JM, Patterson F, Erwin JM, Hof PR, & Allman JM.  (2010)  Structural and Diffusion MRI of a Gorilla Brain Performed Ex-Vivo at 9.4 Tesla. In Broadfield D, Yuan M, Schick K., & Toth N. (Eds). The Human Brain Evolving. Gosport: Stone Age Institute Press.

Kaufman JA, Paul LK, Manaye KF, Granstedt AE, Hof PR, Hakeem AY, & Allman JM. (2008) Selective reduction of Von Economo neuron number in agenesis of the corpus callosum.  Acta Neuropathologica 116: 479-489.

Kaufman JA, Ahrens ET, Laidlaw DH, Zhang S, & Allman JM.  (2005)  Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, Primates: Prosimii) combining histology, structural MRI, and diffusion-tensor imaging (DTI). Anatomical Record 287: 1026-1037.

Kaufman JA.  (2003)  On the expensive-tissue hypothesis: independent support from highly-encephalized fish. Current Anthropology 44: 705-707.

Kaufman JA, Black KJ, Phillips-Conroy J, & Perlmutter J.  (2003)  Asymmetric regional cerebral blood flow in sedated baboons measured by positron emission tomography (PET).  American Journal of Physical Anthropology 121: 369-377.

Kaufman JA & Smith RJ.  (2002)  Statistical issues in the prediction of body mass for pleistocene canids.  Lethaia 35: 32-34.