Jose R Rodriguez Sosa, DVM, MSc, PhD

Assistant Professor


Midwestern University
Arizona College of Osteopathic Medicine
Department of Anatomy
Agave Hall 201V
19555 N 59th Avenue
Glendale, AZ 85308

Office: (623) 572-3235
jrodriguezsosa@midwestern.edu  

EDUCATION

PhD University of Guelph 2007
MSc National Autonomous University of Mexico 1999
DVM University of Veracruz 1996

POSTDOCTORAL TRAINING

Dept. of Comparative Biology and Experimental Medicine, University of Calgary

Center for Animal Transgenesis and Germ cell Research, New Bolton center, University of Pennsylvania  

RESEARCH SUMMARY

Our research is centered in the field of reproductive biology, with the one-health approach. We use the xenotransplantation of testicular tissue and cells from large animals into mice in order to study testicular development and function in these species. The effects of endocrine disruptors on these processes is an important aspect of my research.

Research project Endocrine disruptors (EDs) are chemicals that can mimic or alter hormones that regulate diverse physiological processes. EDs that interfere with the production and action of sex hormones disrupt the reproductive system. Some EDs are found in compounds added to plastics and synthetic resins. In rodents, some plasticizers like DBP inhibit the production of the male sex hormones (anti-androgenic). Thus, the male reproductive system is particularly susceptible to the action of this kind of compounds, whether other mammalian species are susceptible remains unclear. Testicular xenografting is a novel and valuable technique to study the effects of EDs on testicular maturation. This approach uses immunocompromised mice as bioincubators to grow immature testicular tissue from large species. We expose recipient mice to EDs like DBP to determine the effects of this kind of EDs on the testicular maturation of large animals.  

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