Kyle K. Henderson, Ph.D.

Associate Professor

Midwestern University
Chicago College of Osteopathic Medicine (CCOM)
College of Dental Medicine Illinois (CDMI)
Department of Physiology
Department of Osteopathic Manipulative Medicine
Science Hall 422-D
555 31st St.
Downers Grove, IL 60515

Office: (630) 515-6067


B.S. Secondary Education University of Missouri-Columbia 1993
Ph.D. Physiology Kansas University Medical Center 2001


Integrative Cardio-Respiratory Research and Osteopathic Medicine:

Medical research is constantly evolving. As molecular techniques developed, medical research shifted to cell culture studies and pharmacological reactions conducted in test-tubes. However, translation of this medical research to the patient population was hindered by the limitations of 2-D models (cell culture) and non-physiological conditions. My research focuses on how the whole body responds and adapts to environmental stress. This integrative type of research requires an understanding of how tissue and organ systems function and respond to change. For example, my graduate studies focused on how a simple increase in hemoglobin oxygen affinity can change everything from blood viscosity to maximal aerobic performance at extreme altitudes. As a post-doc, I examined the effects of hyperlipidemia and exercise training on coronary endothelial function in a swine animal model, both in vivo (human catheter lab) and in vitro (isolated resistance vessels). As an assistant professor at Loyola University's Cardiovascular Institute, I used several animal models of heart failure and began studying the effect of thyroid hormone on left ventricular remodeling after a heart attack. Currently, we are investigating how Osteopathic Manipulative Medicine (OMM) improves physiological function in health and disease.

Research Projects:

Project 1: The Cranial Rhythmic Impulse (CRI) is one of the most controversial topics in Osteopathic Medicine. Eulerian video magnification (developed by MIT) is being used to determine if the Cranial Rhythmic Impulse (CRI) can be visualized. A Michelson interferometer was also built to measure motion as small as 0.5µm. Current studies are attempting to validate Viola Frymann’s original findings from the 1970’s with state-of-the-art force transducers to differentiate bone vs. tissue motion. Preliminary data suggest Eulerian video magnification can measure human physiological oscillations such as heart rate, respiration rate, and cutaneous arteriole vasomotion associated with local autoregulation. IRB (MWU# 2516) IACUC (MWU #2198).

Project 2: Somatic dysfunction and fascial strain patterns may alter pulmonary function. We are currently investigating: 1) how body posture (internal vs. external rotation) influences thoracic excursion and perceived effort of breathing (clinical goal to optimize nebulizer therapy); and 2) how rib somatic dysfunction (in the absence of pain) may limit thoracic excursion, lung volumes and pulmonary function. IRB (MWU# 2327).

Project 3: Hip extension assessments and inter- and intra-rater reliability.  Because CCOM tends to focus attention on the iliopsoas as a source for low back pain, we are beginning to evaluate the clinical utility and reliability of various hip extension assessments.  This project is in the very early stages of development.

PUBLICATIONS (in reverse chronological order):

  1. Wallace, D.P., J.M. Tomich, T. Iwamoto, K. Henderson, J.J. Grantham, L.P. Sullivan.  A synthetic peptide derived from the glycine-gated Cl- channel induces transepithelial Cl- and fluid secretion.  Am. J. Physiol.  272: C1672-C1679, 1997.
  2. Tomich, J.M., D. Wallace, K. Henderson, K.E. Mitchell, G. Radke, R. Brandt, C.A. Ambler, A.J. Scott, J. Grantham, L. Sullivan, T. Iwamoto.  Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function.             Biophys. J. 74(1): 256-267, 1998.
  3. McCanse, W., K. Henderson, T. Urano, I. Kuwahira, R.L. Clancy, N.C. Gonzalez.  Effect of chronic sodium cyanate administration on O2 transport and uptake in hypoxic and normoxic exercise.  J. Appl. Physiol., 86(4): 1257-1263, 1999.
  4. Henderson, K.K., W., McCanse, T., Urano, I., Kuwahira, R.L. Clancy, N.C. Gonzalez.  Acute vs. Chronic effects of elevated hemoglobin O2 affinity on O2 transport in maximal exercise.  J. Appl. Physiol.  J. Appl. Physiol., 89: 265-272, 2000.
  5. Favret, F., J.P. Richalet, K.K. Henderson, R. Germack, and N.C. Gonzalez.  Myocardial adrenergic and cholinergic receptor function in hypoxia: correlation with O2 transport in exercise.  Am. J. Physiol. Regul. Integr. Comp. Physiol.  280(3):R730-R738, 2001. 
  6. Henderson K.K., R.L. Clancy, N.C. Gonzalez.  Living and training in moderate hypoxia does not improve VO2max more than living and training in normoxia. J. Appl. Physiol. 90(6):2057-2062, 2001.
  7. Favret F., K.K. Henderson, R.L. Clancy, J.P. Richalet and N.C. Gonzalez.  Exercise training alters the effect of chronic hypoxia on myocardial adrenergic and muscarinic receptor number.  J Appl Physiol. 91(3):1283-1288, 2001.
  8. Henderson, K.K., H. Wagner, F. Favret, S.L. Britton, L.G. Koch, P.D. Wagner and N.C. Gonzalez.  Determinants of maximal O2 uptake in rats selectively bred for endurance running capacity.  J. Appl. Physiol. 93(4):1265-1274, 2002.
  9. Laughlin, M.H., W.V. Welshons, M. Sturek, J.W. Rush, J.R. Turk, J.A. Taylor, B.M. Judy, K.K. Henderson and V.K. Ganjam.  Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries.  J. Appl. Physiol.  95(1): 250-264, 2003.
  10. Favret F., K.K. Henderson, J.P. Richalet and N.C. Gonzalez.  Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise.  J Appl Physiol. 95(4):1531-1541, 2003.
  11. Henderson K.K., E.A. Mokelke, J.R. Turk, R.S. Rector, M.H. Laughlin and M. Sturek.  Maintaining patency and asepsis of vascular access ports in Yucatan miniature swine.  Contemporary Topics.  (42) 6: 16-20, 2003.
  12. Liu, Y., R.S. Rector, T.R. Thomas, J.A. Taylor, D.A. Holiman, K.K. Henderson and M. Sturek. Lipoproteins during the estrous cycle in swine.  Metabolism 53(2):140-141, 2003.
  13. Thompson, M.A., K.K. Henderson, C.R. Woodman, J.R. Turk,  J.W.E. Rush, E. Price, and M.H. Laughlin.  Exercise Preserves Endothelium-Dependent Relaxation in Coronary Arteries of Hypercholesterolemic Male Pigs.  J Appl Physiol. 96(3):1114-26, 2004.
  14. Rector RS, Thomas TR, Liu Y, Henderson K.K., Holiman DA, Sun GY, Sturek M. Effect of exercise on postprandial lipemia following a higher calorie meal in Yucatan miniature swine. Metabolism. 53(8):1021-6, 2004.
  15. Henderson K.K., J.R. Turk, J.W.E. Rush, and M.H. Laughlin.  Endothelial function in coronary arterioles from pigs with early-stage coronary disease induced by high-fat, high-cholesterol diet: effect of exercise.  J Appl Physiol. 97(3):1159-68, 2004.
  16. Turk, J.R., K.K. Henderson, G.D. VanVickle, J. Watkins and M.H. Laughlin.  Arterial endothelial function in a procine model of early atherosclerotic vascular disease.  Int J Exp Pathol. 86(5):335-45, 2005.
  17. Gonzalez N.C., R.A. Howlett, K.K. Henderson, L.G. Koch, S.L. Britton, H.E. Wagner, F. Favret, and P.D. Wagner.  Systemic oxygen transport in rats artificially selected for running endurance.  Respir Physiol Neurobiol. 28; 151(2-3):141-50, 2006. 
  18. Gonzalez N.C., K.K. Henderson, F. Favret, and J.P. Richalet.  Comments on Point: Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume".  J Appl Physiol. 99(6):2456, 2005.
  19. Favret F., K.K. Henderson, J. Allen, J.P. Richalet, and N.C. Gonzalez.  Exercise training improves lung gas exchange and attenuates acute hypoxic pulmonary hypertension but does not prevent pulmonary hypertension of prolonged hypoxia. J Appl Physiol, 100(1): 20 - 25, 2006.
  20. Brueggemann L.I., D.R. Markun, K.K. Henderson, L.L. Cribbs, and K.L. Byron.  Pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca2+ entry in vascular smooth muscle cells.  J Pharmacol Exp Ther. 317(2): 488-99, 2006.
  21. Henderson, K.K. and K.L. Byron.  Vasopressin-induced Vasoconstriction: Two Concentration-dependent Signal Transduction Pathways.  J Appl Physiol.  102(4):1402-9, 2007.
  22. Mackie, A.R., L.I. Brueggemann, K.K. Henderson, A.J. Shiels, L.L. Cribbs, K.E. Scrogin, and K.L. Byron.  Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction: based on studies in single cells, pressurized arteries and in vivo measurements of mesenteric vascular resistance.  J Pharmacol Exp Ther. 325(2):475-83, 2008. 
  23. Hart, D.L., M.C. Heidkamp, R. Iyengar, K. Vijayan, E.L. Szotek, J.A. Barakat, M. Leya; M. Henze, K. Scrogin, K.K. Henderson, and A.M. Samarel.  CRNK Gene Transfer Improves Function and Reverses the Myosin Heavy Chain Isoenzyme Switch During Post-Myocardial Infarction Left Ventricular Remodeling.  J Mol Cell Cardiol. 45(1):93-105, 2008.
  24. Henderson, K.K., S. Danzi, J.T. Paul, G. Leya, I. Klein, and A.M. Samarel.  Myocardial infarction and low T3 syndrome:  effect of thyroid hormone replacement on left ventricular function. Circ. Heart Failure. 2:243-252, 2009.  
  25. Carter D.B., K.K. Henderson, I.L. Brisbin Jr., C. Bagshaw, and M. Sturek.  Prevalence of Antibodies to Selected Swine Disease Agents in an Insular Population of Feral Swine.  In Wild Pigs: Biology, Damage, Control Techniques, and Management.  Department of Energy, SRNL-RP-2009-00869.  J. J. Mayer and I. L. Brisbin, Jr. (Eds.). Aiken, South Carolina, USA: Savannah River National Laboratory. 379-386, 2009. 
  26. Koshman, Y.E., S. J. Engman, T. Kim, R. Iyengar, K.K. Henderson, and A.M. Samarel. Role of FRNK Tyrosine Phosphorylation In Vascular Smooth Muscle Spreading and Migration.  Cardiovascular Research. 85:571-581, 2010.
  27. Kottam, A., J. Dubois, A. McElligott and K.K. Henderson. Novel Approach to Admittance to Volume Conversion for Ventricular Volume Measurement.  Conf Proc IEEE Eng Med Biol Soc. 2011:2514-7, 2011.
  28. Govindan S., A. McElligott, S. Muthusamy, N. Nair, D. Barefield, J.L. Martin, E. Gongora, K.D. Greis, P.K. Luther, S. Winegrad, K.K. Henderson, and S. Sadayappan. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.  J Mol Cell Cardiol. Jan; 52(1): 154-64, 2012.
  29. Henderson, K.K., J. Parker, and K. Heinking.   Mountaineering-Induced Bilateral Plantar Paresthesia. J Am Osteopath Assoc. 2014;114(7):549-555. doi:10.7556/jaoa.2014.108.
  30. Zafiratos, M.T., S. Manam, K.K. Henderson, K.H. Ramsey, A.K. Murthy. CD8+ T cells Mediate Chlamydia pneumoniae Induced Atherosclerosis in Mice. Pathogens and Disease 2015. Oct;73(7).
  31. Tamayo, C.A., M. Rizkalla, and K.K. Henderson. Empathy in Pharmacy Students: Targeting Programs for Curriculum Modification. Frontiers in Pharmacology 2016. April 7(96) : 1-8. 
  32. Rizkalla, M., K.K. Henderson, K. Huntington-Alfano, K.P. Heinking, N.D. Krumdick, A. Koronkiewicz, M. Knees, H. Hoffman, F. Elahi, and A. Impens. Does Osteopathic Manipulation Make a Neuropsychological Brain of Difference in Adults with Pain? A BOD Study Protocol and Rational for a New Approach. J Am Osteopath Assoc. in press May 2018.

Review Article or Book Chapter:

  1. Gonzalez, N.C., R.A. Howlett, K.K. Henderson, L.G. Koch, S.L. Britton, H.E. Wagner, F. Favret, P.D. Wagner.  Systemic oxygen transport in rats artificially selected for running endurance. Respir Physiol Neurobiol. 28;151(2-3):141-50, 2006.
  2. Mackie, A. R., K.K. Henderson, S. Misener, and H. Ardehali. (2014) In Vivo Hemodynamics, in Manual of Research Techniques in Cardiovascular Medicine (eds H. Ardehali, R. Bolli and D. W. Losordo), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118495148.ch35

Manuscripts Submitted or in Preparation:

  1. Henderson, K.K., A. McElligott, M. Chu, N. Patel, and J.T. Paul.  Type II deiodinase up-regulation in end-stage human dilated cardiomyopathy. 
  2. Hines, P., K. Heinking, and K.K. Henderson.  Efficacy of Osteopathic Manipulative Treatment on Pulmonary Function in Healthy Adult Male Subjects.