Kyle K. Henderson, Ph.D.

Assistant Professor

Midwestern University
Chicago College of Osteopathic Medicine (CCOM)
College of Dental Medicine Illinois (CDMI)
Department of Physiology
Department of Osteopathic Manipulative Medicine
Science Hall 422-D
555 31st St.
Downers Grove, IL 60515

Office: (630) 515-6067


B.S. Secondary Education University of Missouri-Columbia 1993
Ph.D. Physiology Kansas University Medical Center 2001


Integrative Cardio-Respiratory Research and Osteopathic Medicine:

Medical research is constantly evolving. As molecular techniques developed, medical research shifted to cell culture studies and pharmacological reactions conducted in test-tubes. However, translation of this medical research to the patient population was hindered by the limitations of 2-D models (cell culture) and non-physiological conditions. My research focuses on how the whole body responds and adapts to environmental stress. This integrative type of research requires an understanding of how tissue and organ systems function and respond to change. For example, my graduate studies focused on how a simple increase in hemoglobin oxygen affinity can change everything from blood viscosity to maximal aerobic performance at extreme altitudes. As a post-doc, I examined the effects of hyperlipidemia and exercise training on coronary endothelial function in a swine animal model, both in vivo (human catheter lab) and in vitro (isolated resistance vessels). As an assistant professor at Loyola University's Cardiovascular Institute, I used several animal models of heart failure and began studying the effect of thyroid hormone on left ventricular remodeling after a heart attack. Currently, we are investigating how Osteopathic Manipulative Medicine (OMM) improves physiological function in health and disease.

Research Projects:

Project 1: Thyroid hormone concentrations may decrease after a heart attack attenuating angiogenesis and adaptive left ventricular remodeling. Animal models of heart failure and human heart samples are used to conduct in vivo, imaging, and molecular studies at Midwestern University and Loyola University Medical Center. 

Project 2: Standard treatment for carpal tunnel syndrome involves wrist exercises and surgery. We hypothesize that upper body somatic dysfunction may contribute to carpal tunnel syndrome symptoms. OMM treatment to regions other than the wrist may provide relief to patients in which standard medical treatments have failed.  IRB (MWU#2493).

Project 3: Sympathetic outflow tracts project from the thoraco-lumbar region (T1-L2; Heart and Lungs at T1-T4). This suggests that somatic dysfunction at T1-T4 could alter sympathetic regulation of the heart and lungs. We hypothesize that OMM at T1-T4 will alter the relative contribution of sympathetic control over heart rate variability and pulmonary function. Because sympathetic tone influences airway resistance, these studies may explain some of the contradictory findings associated with OMM and respiratory function. IRB approval pending.

Project 4: The Cranial Rhythmic Impulse (CRI) is one of the most controversial topics in Osteopathic Medicine. Eulerian video magnification (developed by MIT) is being used to determine if the Cranial Rhythmic Impulse (CRI) can be visualized. A Michelson interferometer was built to measure motion as small as 0.5µm. Preliminary data suggest Eulerian video magnification can measure human physiological oscillations such as heart rate, respiration rate, and a low frequency oscillation linked to changes in tissue blood flow velocity.  IRB (MWU# 2516) IACUC (MWU #2198).

PUBLICATIONS (in reverse chronological order):

  1. Wallace, D.P., J.M. Tomich, T. Iwamoto, K. Henderson, J.J. Grantham, L.P. Sullivan.  A synthetic peptide derived from the glycine-gated Cl- channel induces transepithelial Cl- and fluid secretion.  Am. J. Physiol.  272: C1672-C1679, 1997.
  2. Tomich, J.M., D. Wallace, K. Henderson, K.E. Mitchell, G. Radke, R. Brandt, C.A. Ambler, A.J. Scott, J. Grantham, L. Sullivan, T. Iwamoto.  Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function.             Biophys. J. 74(1): 256-267, 1998.
  3. McCanse, W., K. Henderson, T. Urano, I. Kuwahira, R.L. Clancy, N.C. Gonzalez.  Effect of chronic sodium cyanate administration on O2 transport and uptake in hypoxic and normoxic exercise.  J. Appl. Physiol., 86(4): 1257-1263, 1999.
  4. Henderson, K.K., W., McCanse, T., Urano, I., Kuwahira, R.L. Clancy, N.C. Gonzalez.  Acute vs. Chronic effects of elevated hemoglobin O2 affinity on O2 transport in maximal exercise.  J. Appl. Physiol.  J. Appl. Physiol., 89: 265-272, 2000.
  5. avret, F., J.P. Richalet, K.K. Henderson, R. Germack, and N.C. Gonzalez.  Myocardial adrenergic and cholinergic receptor function in hypoxia: correlation with O2 transport in exercise.  Am. J. Physiol. Regul. Integr. Comp. Physiol.  280(3):R730-R738, 2001. 
  6. Henderson K.K., R.L. Clancy, N.C. Gonzalez.  Living and training in moderate hypoxia does not improve VO2max more than living and training in normoxia. J. Appl. Physiol. 90(6):2057-2062, 2001.
  7. Favret F., K.K. Henderson, R.L. Clancy, J.P. Richalet and N.C. Gonzalez.  Exercise training alters the effect of chronic hypoxia on myocardial adrenergic and muscarinic receptor number.  J Appl Physiol. 91(3):1283-1288, 2001.
  8. Henderson, K.K., H. Wagner, F. Favret, S.L. Britton, L.G. Koch, P.D. Wagner and N.C. Gonzalez.  Determinants of maximal O2 uptake in rats selectively bred for endurance running capacity.  J. Appl. Physiol. 93(4):1265-1274, 2002.
  9. Laughlin, M.H., W.V. Welshons, M. Sturek, J.W. Rush, J.R. Turk, J.A. Taylor, B.M. Judy, K.K. Henderson and V.K. Ganjam.  Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries.  J. Appl. Physiol.  95(1): 250-264, 2003.
  10. Favret F., K.K. Henderson, J.P. Richalet and N.C. Gonzalez.  Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise.  J Appl Physiol. 95(4):1531-1541, 2003.
  11. Henderson K.K., E.A. Mokelke, J.R. Turk, R.S. Rector, M.H. Laughlin and M. Sturek.  Maintaining patency and asepsis of vascular access ports in Yucatan miniature swine.  Contemporary Topics.  (42) 6: 16-20, 2003.
  12. Liu, Y., R.S. Rector, T.R. Thomas, J.A. Taylor, D.A. Holiman, K.K. Henderson and M. Sturek. Lipoproteins during the estrous cycle in swine.  Metabolism 53(2):140-141, 2003.
  13. Thompson, M.A., K.K. Henderson, C.R. Woodman, J.R. Turk,  J.W.E. Rush, E. Price, and M.H. Laughlin.  Exercise Preserves Endothelium-Dependent Relaxation in Coronary Arteries of Hypercholesterolemic Male Pigs.  J Appl Physiol. 96(3):1114-26, 2004.
  14. Rector RS, Thomas TR, Liu Y, Henderson K.K., Holiman DA, Sun GY, Sturek M. Effect of exercise on postprandial lipemia following a higher calorie meal in Yucatan miniature swine. Metabolism. 53(8):1021-6, 2004.
  15. Henderson K.K., J.R. Turk, J.W.E. Rush, and M.H. Laughlin.  Endothelial function in coronary arterioles from pigs with early-stage coronary disease induced by high-fat, high-cholesterol diet: effect of exercise.  J Appl Physiol. 97(3):1159-68, 2004.
  16. Turk, J.R., K.K. Henderson, G.D. VanVickle, J. Watkins and M.H. Laughlin.  Arterial endothelial function in a procine model of early atherosclerotic vascular disease.  Int J Exp Pathol. 86(5):335-45, 2005.
  17. Gonzalez N.C., R.A. Howlett, K.K. Henderson, L.G. Koch, S.L. Britton, H.E. Wagner, F. Favret, and P.D. Wagner.  Systemic oxygen transport in rats artificially selected for running endurance.  Respir Physiol Neurobiol. 28; 151(2-3):141-50, 2006. 
  18. Gonzalez N.C., K.K. Henderson, F. Favret, and J.P. Richalet.  Comments on Point: Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume".  J Appl Physiol. 99(6):2456, 2005.
  19. Favret F., K.K. Henderson, J. Allen, J.P. Richalet, and N.C. Gonzalez.  Exercise training improves lung gas exchange and attenuates acute hypoxic pulmonary hypertension but does not prevent pulmonary hypertension of prolonged hypoxia. J Appl Physiol, 100(1): 20 - 25, 2006.
  20. Brueggemann L.I., D.R. Markun, K.K. Henderson, L.L. Cribbs, and K.L. Byron.  Pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca2+ entry in vascular smooth muscle cells.  J Pharmacol Exp Ther. 317(2): 488-99, 2006.
  21. Henderson, K.K. and K.L. Byron.  Vasopressin-induced Vasoconstriction: Two Concentration-dependent Signal Transduction Pathways.  J Appl Physiol.  102(4):1402-9, 2007.
  22. Mackie, A.R., L.I. Brueggemann, K.K. Henderson, A.J. Shiels, L.L. Cribbs, K.E. Scrogin, and K.L. Byron.  Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction: based on studies in single cells, pressurized arteries and in vivo measurements of mesenteric vascular resistance.  J Pharmacol Exp Ther. 325(2):475-83, 2008. 
  23. Hart, D.L., M.C. Heidkamp, R. Iyengar, K. Vijayan, E.L. Szotek, J.A. Barakat, M. Leya; M. Henze, K. Scrogin, K.K. Henderson, and A.M. Samarel.  CRNK Gene Transfer Improves Function and Reverses the Myosin Heavy Chain Isoenzyme Switch During Post-Myocardial Infarction Left Ventricular Remodeling.  J Mol Cell Cardiol. 45(1):93-105, 2008.
  24. Henderson, K.K., S. Danzi, J.T. Paul, G. Leya, I. Klein, and A.M. Samarel.  Myocardial infarction and low T3 syndrome:  effect of thyroid hormone replacement on left ventricular function. Circ. Heart Failure. 2:243-252, 2009.  
  25. Carter D.B., K.K. Henderson, I.L. Brisbin Jr., C. Bagshaw, and M. Sturek.  Prevalence of Antibodies to Selected Swine Disease Agents in an Insular Population of Feral Swine.  In Wild Pigs: Biology, Damage, Control Techniques, and Management.  Department of Energy, SRNL-RP-2009-00869.  J. J. Mayer and I. L. Brisbin, Jr. (Eds.). Aiken, South Carolina, USA: Savannah River National Laboratory. 379-386, 2009. 
  26. Koshman, Y.E., S. J. Engman, T. Kim, R. Iyengar, K.K. Henderson, and A.M. Samarel. Role of FRNK Tyrosine Phosphorylation In Vascular Smooth Muscle Spreading and Migration.  Cardiovascular Research. 85:571-581, 2010.
  27. Kottam, A., J. Dubois, A. McElligott and K.K. Henderson. Novel Approach to Admittance to Volume Conversion for Ventricular Volume Measurement.  Conf Proc IEEE Eng Med Biol Soc. 2011:2514-7, 2011.
  28. Govindan S., A. McElligott, S. Muthusamy, N. Nair, D. Barefield, J.L. Martin, E. Gongora, K.D. Greis, P.K. Luther, S. Winegrad, K.K. Henderson, and S. Sadayappan. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.  J Mol Cell Cardiol. Jan; 52(1): 154-64, 2012.
  29. Henderson, K.K., J. Parker, and K. Heinking.   Mountaineering-Induced Bilateral Plantar Paresthesia. J Am Osteopath Assoc. 2014;114(7):549-555. doi:10.7556/jaoa.2014.108.

Review Article or Book Chapter:

  1. Gonzalez, N.C., R.A. Howlett, K.K. Henderson, L.G. Koch, S.L. Britton, H.E. Wagner, F. Favret, P.D. Wagner.  Systemic oxygen transport in rats artificially selected for running endurance. Respir Physiol Neurobiol. 28;151(2-3):141-50, 2006.
  2. Mackie, A. R., K.K. Henderson, S. Misener, and H. Ardehali. (2014) In Vivo Hemodynamics, in Manual of Research Techniques in Cardiovascular Medicine (eds H. Ardehali, R. Bolli and D. W. Losordo), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118495148.ch35

Manuscripts Submitted or in Preparation:

  1. Henderson, K.K., A. McElligott, M. Chu, N. Patel, and J.T. Paul.  Type II deiodinase up-regulation in end-stage human dilated cardiomyopathy. 
  2. Hines, P., K. Heinking, and K.K. Henderson.  Efficacy of Osteopathic Manipulative Treatment on Pulmonary Function in Healthy Adult Male Subjects.