Michael H. Jaffe, DVM, MS, DACVS

Assistant Professor Small Animal Surgery


Midwestern University
College of Veterinary Medicine
Department of Small Animal Surgery
323-G Companion Animal Clinic
19555 59th Ave.
Glendale, AZ 85308

Office: (623) 806-7480
e-mail: mjaffe@midwestern.edu

EDUCATION

B.S. Zoology University of Massachusetts 1986
D.V.M Vet Med University of Missouri 1991
M.S Vet Clin Sci Louisiana State University 1999
DACVS 2002

RESEARCH SUMMARY

Laser tissue welding is a suture-less surgical method for the anastomosis of incised tissue. This is achieved by tissue absorption of laser light converted to heat energy, resulting in deformation of tissue proteins at ~60oC and their eventual fusion upon cooling. Fusion of photo-thermally altered collagen via covalent and electrostatic interactions is the mechanisms by which tissue welding results. Preliminary data using ex vivo porcine intestine showed that a plasmonic nanocomposite, generated from elastin-like polypeptides cross linked with gold nanorods, could be used to weld intestinal tissue subsequent to exposure to a near-infrared laser. Pressure testing of the welded tissue following treatment demonstrated decreased anastomotic leakage. My current research involves the assessment of healing in a mouse colotomy model following laser tissue welding with a gold nanorod-collagen composite following treatment with a near infra-red laser.

Research project

Since 2014, I have been be working in collaboration with the department of Chemical Engineering, Arizona State University and the Department of Surgery, Mayo Clinic Scottsdale, AZ in the evaluation of a gold nano-rod with collagen to be used for laser tissue welding. The nano-composite is placed in vivo at the site of a colotomy in mice. The tissue is then treated with a near infra-red laser to create the tissue weld. After 7 days the colon sections are evaluated histologically for healing, gross signs of peritonitis, tissue bursting pressure is tested and leakage from the colotomy site is assessed.

Selected Publications

Gold Nanorod-Collagen Nanocomposites as Photothermal Nanosolders for Laser Welding of Ruptured Porcine Intestines Russell Urie, Sana Quraishi, Michael Jaffe, Kaushal Reg. ACS Biomater. Sci. Eng., 2015, 1 (9), pp 805-815.

Decreased surgical time with a vessel sealing device versus a surgical stapler in performance of canine splenectomy. Monarski CJ, Jaffe MH, Kass PH. J Am Anim Hosp Assoc. 2014 Jan-Feb;50(1):42-5. doi: 10.5326/JAAHA-MS-5981.

Evaluation of two novel self-anchoring barbed sutures in a prophylactic laparoscopic gastropexy compared with intracorporeal tied knots. Spah CE, Elkins AD, Wehrenberg A, Jaffe MH, Baird DK, Naughton JF, Payton ME. Vet Surg. 2013 Nov;42(8):932-42. doi: 10.1111/j.1532-950X.2013.12043.x.