Michael R. Kozlowski, O.D., Ph.D.

Associate Professor


    

Midwestern University
Arizona College of Optometry
Glendale Hall, Suite 127
19555 N. 59th Avenue
Glendale, AZ 85308
Office: (623) 572-3915
e-mail: mkozlo@midwestern.edu

 

 

EDUCATION

B.S. Biology California Institute of Technology
Ph.D. Psychobiology University of California, Irvine
O.D. Optometry The New England College of Optometry

RESEARCH SUMMARY

The research in my laboratory is focused on discovering new drugs for significant unmet clinical needs.  Our current emphasis is on disorders of the eye, such as age-related macular degeneration (AMD) and glaucoma, and cancer.

Research Projects

Age-related Macular Degeneration (AMD)

Our working hypothesis is that the occurrence of AMD is related to senescence in the retinal pigment epithelial (RPE) cells of the eye (see Selected Publications, below).  Agents that are able to inhibit or reverse RPE cell senescence may, therefore, represent new treatments for AMD.  We are using both cell-based assays and model systems to discover and profile agents with this activity.

Glaucoma

There is a growing body of evidence that senescence epithelial cells in Sclemm's canal (SC) may contribute to the pathology of primary open angle glaucoma.  We are using a cell-based system to study the effects of senescence on SC epithelial cells and to search for agents that inhibit their senescence.  Such agents may lead to more effective and safer treatment for glaucoma.

Cancer

Peptides of the atrial natriuretic family have shown the ability to inhibit the growth of a number of types of cancer both in vitro and in vivo.  We are working with Kalos Therapeutics Inc. to develop a new class of anti-cancer drugs from these peptides.

Selected Publications

Kozlowski, M.R., RPE cell senescence: A key contributor to age-related macular degeneration, Medical Hypotheses 78, 505-510, 2012.

Kozlowski, M. R., "The ARPE-19 cell line:  mortality status and utility in macular degeneration research." Current Eye Research, published ahead of print: doi:10.3109/027 13683.2014.935440, 1-9, 2014a.

Kozlowski, M. R.,  "Senescent RPE cells are more sensitive to VEFG:  Implications for "wet" AMD." Journal of Ocular Pharmacology and Therapeutics, published ahead of print: doi: 10.1089/jop.2014.0071, 2014b.