Shankar Thangamani, D.V.M., Ph.D.

Assistant Professor


Dr. Shankar ThangamaniAssistant Professor   
Midwestern University 
College of Veterinary Medicine
Department of Pathology and Population Medicine 
Cactus Wren 336-N
19555 N. 59th Ave. Glendale, AZ 85308

Office: (623) 537-6378
e-mail: sthang@midwestern.edu  

 

 

 

 

EDUCATION

Ph.D. Microbiology and Immunology Purdue University 2016
D.V.M. Veterinary Medicine Madras Veterinary College, India 2009

RESEARCH SUMMARY

My laboratory is interested in understanding various aspects of bacterial and fungal diseases. We aim to understand (i) how imbalance in gut microbiota leads to enteric opportunistic infections including candidiasis (ii) the role of gut commensals in xenobiotic metabolism (iii) and understanding fungal pathogenesis in cancer patients.

Utilizing various molecular and sequencing tools, in vitro and in vivo experimental approaches, understanding the bacterial and fungal pathogenesis in various aspects will guide personalized medicine and improve drug discovery and development.

My laboratory is also interested in developing novel treatment and control strategies for infectious diseases of humans and animals. Research in this area includes RNA vaccine development, delivery platforms for vaccines, small molecule inhibitors for infectious diseases and explore microbiome therapeutics for the treatment of infectious diseases.

SELECTED PUBLICATIONS

Thangamani S, M. Maland, H. Mohammad, P. Pascuzzi, L. Avramova, C. Koehler, T. R. Hazbun and M. N. Seleem. Repurposing approach identifies auranofin with broad spectrum antifungal activity that targets Mia40-Erv1 pathway, Frontiers in Cellular and Infection Microbiology. 2017.  

Thangamani S, H. E. Eldesouky, H. Mohammad, P. Pascuzzi, L. Avramova, T. R. Hazbun and M. N. Seleem. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. BBA- General Subjects. 2016 Oct 3;1861(1 Pt A):3002-3010.   

Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN. Repurposing auranofin for the treatment of cutaneous staphylococcal infections. International Journal of Antimicrobial agents and Chemotherapy. 2016 Jan 23; S0924-8579(16)00012-1.  

Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN. Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent. Scientific Reports. 2015 Nov 10;5:16407.  

Thangamani S*, Kim M*, Son Y, Huang X, Kim H, Lee JH, Cho J, Ulrich B, Broxmeyer HE, Kim CH. Cutting edge: progesterone directly up regulates vitamin d receptor gene expression for efficient regulation of T cells by calcitriol. Journal of Immunology. 2015 Feb 1;194(3):883-6. (* Co-first authors).  

https://www.ncbi.nlm.nih.gov/pubmed/?term=shankar+thangamani