T. Bucky Jones, Ph.D.

Associate Professor


Midwestern University
Dept. of Anatomy
19555 N. 59th Ave
Glendale AZ   85308
Phone: 623-572-3733
Email: bjones1@midwestern.edu

EDUCATION

Ph.D. (Neuroscience), The Ohio State University, Columbus, Ohio
M.S. (Kinesiology), Washington State University, Pullman, Washington
B.A. (Business Administration), University of Washington, Seattle, Washington  

RESEARCH SUMMARY

A large area of research focus in my laboratory is understanding the implications of immune activation on the extent of tissue damage and associated effects on the recovery of function following contusion or compression injury to the spinal cord.  My early research in this area was instrumental in the recognition that trauma to the CNS induces autoimmune responses against CNS components that can aggravate a patient's condition. This initial work in spinal cord injury was recognized as having relevance for Alzheimer disease (AD) at a time in which therapeutic vaccines were initially being developed as a means to slow the accumulation of plaques in the diseased brain. My research emphasized the potentially deleterious impact of initiating autoimmunity in AD patients by trying to stimulate their immune systems to fight the disease.  Recent projects in the laboratory are aimed at determining the effects of modulating the renin-angiotensin system on the inflammatory response in spinal cord injury and Alzheimer disease models. 

PUBLICATIONS

Modulation of NK cell cytolytic activity by macrophages in chronically exercise-stressed mice. Blank SE, Jones TB, Lee EG, Brahler CJ, Gallucci RM, Fox ML, Meadows GG.J Appl Physiol (1985). 1997 Sep;83(3):845-50. PMID: 9292472

Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy. Jones TB, Basso DM, Sodhi A, Pan JZ, Hart RP, MacCallum RC, Lee S, Whitacre CC, Popovich PG.J Neurosci. 2002 Apr 1;22(7):2690-700. PMID: 11923434

Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Popovich PG, Jones TB.Trends Pharmacol Sci. 2003 Jan;24(1):13-7. Review. PMID: 12498725

Rats and mice exhibit distinct inflammatory reactions after spinal cord injury. Sroga JM, Jones TB, Kigerl KA, McGaughy VM, Popovich PG.J Comp Neurol. 2003 Jul 21;462(2):223-40. PMID: 12794745

Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats. Jones TB, Ankeny DP, Guan Z, McGaughy V, Fisher LC, Basso DM, Popovich PG.J Neurosci. 2004 Apr 14;24(15):3752-61. PMID: 15084655

Molecular control of physiological and pathological T-cell recruitment after mouse spinal cord injury. Jones TB, Hart RP, Popovich PG.J Neurosci. 2005 Jul 13;25(28):6576-83. PMID: 16014718

Inflammatory-mediated injury and repair in the traumatically injured spinal cord. Jones TB, McDaniel EE, Popovich PG.Curr Pharm Des. 2005;11(10):1223-36. Review. PMID: 15853679

Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Lucin KM, Sanders VM, Jones TB, Malarkey WB, Popovich PG.Exp Neurol. 2007 Sep;207(1):75-84. Epub 2007 Jun 2. PMID: 17597612

T.B. Jones, K.M. Lucin, and P.G. Popovich. The Immune System of the Brain in Neuroimmune Biology, Volume 7: 127-144. A.D. Rey, G. Chrousos, H. Besedovsky (Eds), Elsevier Science, 2008.   

Cellular neuroinflammation in a lateral forceps compression model of spinal cord injury. Vaughn CN, Iafrate JL, Henley JB, Stevenson EK, Shlifer IG, Jones TB.Anat Rec (Hoboken). 2013 Aug;296(8):1229-46. doi: 10.1002/ar.22730. Epub 2013 Jun 17. PMID: 23775900

Lymphocytes and autoimmunity after spinal cord injury. Jones TB.Exp Neurol. 2014 Aug;258:78-90. doi: 10.1016/j.expneurol.2014.03.003. Review. PMID: 25017889