Tom L. Broderick, PhD

Professor


Midwestern University
Arizona College of Osteopathic Medicine
Department of Physiology 
Laboratory of Diabetes and Exercise Metabolism
Agave Hall, Room 217-C
19555 North 59th avenue
Glendale, AZ, 85308
Office: (623) 572-3664
e-mail: tbrode@midwestern.edu

EDUCATION

B.P.E. Sport Sciences/Biology University of New Brunswick (Fredericton) 1986
M.Sc. Physiology/Endocrinology Université Laval (Quebec) 1989
Ph.D. Exercise Studies, University of Alberta (Edmonton) Université Laval (Quebec) 1993

RESEARCH

Exercise performed on a regular basis is generally recommended to treat metabolic disorders. My research is centered on how mouse models of diabetes and obesity respond to different exercise paradigms. Specifically, I investigate the effects of acute, voluntary, and forced exercise on liver and heart in defective leptin-signalling mice. I am interested in understanding how exercise in the db/db mouse, which displays hypercortisolism, alters liver gluconeogenic function and glucose control. In the heart, I am primarily interested how exercise activates genes and proteins involved in cardioprotection. Interestingly, certain mouse models of diabetes also exhibit abnormalities in carnitine homeostasis. My laboratory is also focusing how the diabetic state affects renal excretion of carnitine as well as carnitine biosynthesis by various tissues.

SELECTED PUBLICATIONS

A complete list of my publications in the field of diabetes and cardiomyopathy, exercise training in mouse models of type 2 diabetes and obesity, and carnitine homeostasis in carnitine deficiency syndromes can be viewed on PubMed (Click here to view my full list)